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==Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution== | |||
<StructureSection load='4x30' size='340' side='right'caption='[[4x30]], [[Resolution|resolution]] 1.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4x30]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X30 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=T44:3,5,3,5-TETRAIODO-L-THYRONINE'>T44</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x30 OCA], [https://pdbe.org/4x30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x30 RCSB], [https://www.ebi.ac.uk/pdbsum/4x30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x30 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:[https://omim.org/entry/314200 314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN] Major thyroid hormone transport protein in serum. | |||
==See Also== | |||
*[[Serpin 3D structures|Serpin 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Qi X]] | |||
Latest revision as of 18:24, 8 November 2023
Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolutionCrystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution
Structural highlights
DiseaseTHBG_HUMAN Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:314200. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid. FunctionTHBG_HUMAN Major thyroid hormone transport protein in serum. See Also |
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