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[[Image:2d54.jpg|left|200px]]<br /><applet load="2d54" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2d54, resolution 2.0&Aring;" />
'''Crystal Structure of Methionyl tRNA Synthetase Y225A Mutant from Thermus Thermophilus'''<br />


==About this Structure==
==Crystal Structure of Methionyl tRNA Synthetase Y225A Mutant from Thermus Thermophilus==
2D54 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D54 OCA].  
<StructureSection load='2d54' size='340' side='right'caption='[[2d54]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
[[Category: Methionine--tRNA ligase]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2d54]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D54 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d54 OCA], [https://pdbe.org/2d54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d54 RCSB], [https://www.ebi.ac.uk/pdbsum/2d54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d54 ProSAT], [https://www.topsan.org/Proteins/RSGI/2d54 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYM_THET8 SYM_THET8] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d5/2d54_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d54 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Ishii, R.]]
[[Category: Ishii R]]
[[Category: Konno, M.]]
[[Category: Konno M]]
[[Category: Mori, Y.]]
[[Category: Mori Y]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Takasaka R]]
[[Category: Takasaka, R.]]
[[Category: Takeda R]]
[[Category: Takeda, R.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: ZN]]
[[Category: class 1a aars]]
[[Category: isomerase]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rossmann fold]]
[[Category: rsgi]]
[[Category: structural genomics]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:55:26 2008''

Latest revision as of 11:24, 25 October 2023

Crystal Structure of Methionyl tRNA Synthetase Y225A Mutant from Thermus ThermophilusCrystal Structure of Methionyl tRNA Synthetase Y225A Mutant from Thermus Thermophilus

Structural highlights

2d54 is a 1 chain structure with sequence from Thermus thermophilus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

SYM_THET8 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2d54, resolution 2.00Å

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