6aw7: Difference between revisions
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<StructureSection load='6aw7' size='340' side='right'caption='[[6aw7]], [[Resolution|resolution]] 2.15Å' scene=''> | <StructureSection load='6aw7' size='340' side='right'caption='[[6aw7]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6aw7]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6aw7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nannospalax_galili Nannospalax galili]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AW7 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aw7 OCA], [https://pdbe.org/6aw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aw7 RCSB], [https://www.ebi.ac.uk/pdbsum/6aw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aw7 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A452CSQ0_NANGA A0A452CSQ0_NANGA] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.[ARBA:ARBA00003256] | |||
==See Also== | |||
*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Nannospalax galili]] | ||
[[Category: Battaile | [[Category: Battaile KP]] | ||
[[Category: Deng | [[Category: Deng Y]] | ||
[[Category: Hanzlik | [[Category: Hanzlik RP]] | ||
[[Category: Lovell | [[Category: Lovell S]] | ||
[[Category: Mehzabeen | [[Category: Mehzabeen N]] | ||
[[Category: Moskovitz | [[Category: Moskovitz J]] | ||
[[Category: Shams | [[Category: Shams I]] | ||
Latest revision as of 17:26, 4 October 2023
2.15A resolution structure of SAH bound catechol O-methyltransferase (COMT) from Nannospalax galili2.15A resolution structure of SAH bound catechol O-methyltransferase (COMT) from Nannospalax galili
Structural highlights
FunctionA0A452CSQ0_NANGA Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.[ARBA:ARBA00003256] See Also |
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