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[[Image:1sbt.png|left|200px]]


{{STRUCTURE_1sbt|  PDB=1sbt  |  SCENE=  }}
==ATOMIC COORDINATES FOR SUBTILISIN BPN (OR NOVO)==
 
<StructureSection load='1sbt' size='340' side='right'caption='[[1sbt]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===ATOMIC COORDINATES FOR SUBTILISIN BPN (OR NOVO)===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1sbt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_amyloliquefaciens Bacillus amyloliquefaciens]. The October 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''PDB Pioneers''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_10 10.2210/rcsb_pdb/mom_2011_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SBT FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sbt OCA], [https://pdbe.org/1sbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sbt RCSB], [https://www.ebi.ac.uk/pdbsum/1sbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sbt ProSAT]</span></td></tr>
[[1sbt]] is a 1 chain structure of [[Subtilisin]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_amyloliquefaciens Bacillus amyloliquefaciens]. The October 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''PDB Pioneers''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_10 10.2210/rcsb_pdb/mom_2011_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBT OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/SUBT_BACAM SUBT_BACAM] Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides. Has a high substrate specificity to fibrin.<ref>PMID:12524032</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sb/1sbt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sbt ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Subtilisin|Subtilisin]]
*[[Subtilisin 3D structures|Subtilisin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:005160720</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Bacillus amyloliquefaciens]]
[[Category: Bacillus amyloliquefaciens]]
[[Category: Hydrolase]]
[[Category: Large Structures]]
[[Category: PDB Pioneers]]
[[Category: PDB Pioneers]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Alden, R A.]]
[[Category: Alden RA]]
[[Category: Birktoft, J J.]]
[[Category: Birktoft JJ]]
[[Category: Kraut, J.]]
[[Category: Kraut J]]
[[Category: Robertus, J D.]]
[[Category: Robertus JD]]
[[Category: Wright, C S.]]
[[Category: Wright CS]]

Latest revision as of 10:04, 27 September 2023

ATOMIC COORDINATES FOR SUBTILISIN BPN (OR NOVO)ATOMIC COORDINATES FOR SUBTILISIN BPN (OR NOVO)

Structural highlights

1sbt is a 1 chain structure with sequence from Bacillus amyloliquefaciens. The October 2011 RCSB PDB Molecule of the Month feature on PDB Pioneers by David Goodsell is 10.2210/rcsb_pdb/mom_2011_10. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SUBT_BACAM Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides. Has a high substrate specificity to fibrin.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Peng Y, Huang Q, Zhang RH, Zhang YZ. Purification and characterization of a fibrinolytic enzyme produced by Bacillus amyloliquefaciens DC-4 screened from douchi, a traditional Chinese soybean food. Comp Biochem Physiol B Biochem Mol Biol. 2003 Jan;134(1):45-52. PMID:12524032

1sbt, resolution 2.50Å

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