3c4h: Difference between revisions

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-{{Seed}}
-[[Image:3c4h.png|left|200px]]
-<!--
+==Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313==
-The line below this paragraph, containing "STRUCTURE_3c4h", creates the "Structure Box" on the page.
+<StructureSection load='3c4h' size='340' side='right'caption='[[3c4h]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3c4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C4H FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DRL:2-METHYL-3,5,7,8-TETRAHYDRO-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE'>DRL</scene></td></tr>
-{{STRUCTURE_3c4h|  PDB=3c4h  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c4h OCA], [https://pdbe.org/3c4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c4h RCSB], [https://www.ebi.ac.uk/pdbsum/3c4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c4h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/3c4h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c4h ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Poly(ADP-ribose) polymerases (PARPs) activate DNA repair mechanisms upon stress- and cytotoxin-induced DNA damage, and inhibition of PARP activity is a lead in cancer drug therapy. We present a structural and functional analysis of the PARP domain of human PARP-3 in complex with several inhibitors. Of these, KU0058948 is the strongest inhibitor of PARP-3 activity. The presented crystal structures highlight key features for potent inhibitor binding and suggest routes for creating isoenzyme-specific PARP inhibitors.
-===Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313===
+Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.,Lehtio L, Jemth AS, Collins R, Loseva O, Johansson A, Markova N, Hammarstrom M, Flores A, Holmberg-Schiavone L, Weigelt J, Helleday T, Schuler H, Karlberg T J Med Chem. 2009 May 14;52(9):3108-11. PMID:19354255<ref>PMID:19354255</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3c4h" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_19354255}}, adds the Publication Abstract to the page
+*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 19354255 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_19354255}}
+__TOC__
+</StructureSection>
-==About this Structure==
-C4H is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C4H OCA].
-==Reference==
-<ref group="xtra">PMID:19354255</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Berg, S Van den.]]
+[[Category: Arrowsmith CH]]
-[[Category: Berglund, H.]]
+[[Category: Berglund H]]
-[[Category: Bountra, C.]]
+[[Category: Bountra C]]
-[[Category: Busam, R.]]
+[[Category: Busam R]]
-[[Category: Collins, R.]]
+[[Category: Collins R]]
-[[Category: Dahlgren, L G.]]
+[[Category: Dahlgren LG]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards AM]]
-[[Category: Flodin, S.]]
+[[Category: Flodin S]]
-[[Category: Flores, A.]]
+[[Category: Flores A]]
-[[Category: Graslund, S.]]
+[[Category: Graslund S]]
-[[Category: Hammarstrom, M.]]
+[[Category: Hammarstrom M]]
-[[Category: Herman, M D.]]
+[[Category: Herman MD]]
-[[Category: Johansson, A.]]
+[[Category: Johansson A]]
-[[Category: Johansson, I.]]
+[[Category: Johansson I]]
-[[Category: Kallas, A.]]
+[[Category: Kallas A]]
-[[Category: Karlberg, T.]]
+[[Category: Karlberg T]]
-[[Category: Kotenyova, T.]]
+[[Category: Kotenyova T]]
-[[Category: Lehtio, L.]]
+[[Category: Lehtio L]]
-[[Category: Moche, M.]]
+[[Category: Moche M]]
-[[Category: Nilsson, M E.]]
+[[Category: Nilsson ME]]
-[[Category: Nordlund, P.]]
+[[Category: Nordlund P]]
-[[Category: Nyman, T.]]
+[[Category: Nyman T]]
-[[Category: Persson, C.]]
+[[Category: Persson C]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Sagemark J]]
-[[Category: Sagemark, J.]]
+[[Category: Svensson L]]
-[[Category: Svensson, L.]]
+[[Category: Thorsell AG]]
-[[Category: Thorsell, A G.]]
+[[Category: Tresaugues L]]
-[[Category: Tresaugues, L.]]
+[[Category: Van den Berg S]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt J]]
-[[Category: Welin, M.]]
+[[Category: Welin M]]
-[[Category: Alternative splicing]]
-[[Category: Catalytic fragment]]
-[[Category: Enzyme-inhibitor complex]]
-[[Category: Glycosyltransferase]]
-[[Category: Nad]]
-[[Category: Nucleus]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-[[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 08:57:37 2009''