2pzn: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2pzn.jpg|left|200px]]
-<!--
+==The crystallographic structure of Aldose Reductase IDD393 complex confirms Leu300 as a specificity determinant==
-The line below this paragraph, containing "STRUCTURE_2pzn", creates the "Structure Box" on the page.
+<StructureSection load='2pzn' size='340' side='right'caption='[[2pzn]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2pzn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PZN FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=393:(5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC+ACID'>393</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-{{STRUCTURE_2pzn|  PDB=2pzn  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pzn OCA], [https://pdbe.org/2pzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pzn RCSB], [https://www.ebi.ac.uk/pdbsum/2pzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pzn ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pz/2pzn_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pzn ConSurf].
+<div style="clear:both"></div>
-'''The crystallographic structure of Aldose Reductase IDD393 complex confirms Leu300 as a specificity determinant'''
+==See Also==
+*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-PZN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PZN OCA].
-[[Category: Aldehyde reductase]]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Darmanin, C.]]
+[[Category: Darmanin C]]
-[[Category: El-Kabbani, O.]]
+[[Category: El-Kabbani O]]
-[[Category: Hazemann, I.]]
+[[Category: Hazemann I]]
-[[Category: Joachimiak, A.]]
+[[Category: Joachimiak A]]
-[[Category: Mitschler, A.]]
+[[Category: Mitschler A]]
-[[Category: Podjarny, A.]]
+[[Category: Podjarny A]]
-[[Category: Ruiz, F.]]
+[[Category: Ruiz F]]
-[[Category: Zandt, M Van.]]
+[[Category: Van Zandt M]]
-[[Category: Aldose reductase]]
-[[Category: Atomic resolution]]
-[[Category: Inhibitor binding]]
-[[Category: Oxidoreductase]]
-[[Category: Ternary complex]]
-[[Category: X-ray crystallography]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:14:05 2008''