2gry: Difference between revisions

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New page: left|200px<br /> <applet load="2gry" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gry, resolution 2.350Å" /> '''Crystal structure ...
 
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[[Image:2gry.gif|left|200px]]<br />
<applet load="2gry" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2gry, resolution 2.350&Aring;" />
'''Crystal structure of the human KIF2 motor domain in complex with ADP'''<br />


==About this Structure==
==Crystal structure of the human KIF2 motor domain in complex with ADP==
2GRY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG, ADP and UNX as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GRY OCA].  
<StructureSection load='2gry' size='340' side='right'caption='[[2gry]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2gry]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GRY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gry OCA], [https://pdbe.org/2gry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gry RCSB], [https://www.ebi.ac.uk/pdbsum/2gry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gry ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KIF2A_HUMAN KIF2A_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/KIF2A_HUMAN KIF2A_HUMAN] Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.<ref>PMID:15843429</ref> <ref>PMID:17538014</ref> <ref>PMID:18411309</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/2gry_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gry ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Kinesin 3D Structures|Kinesin 3D Structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.H.]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev A]]
[[Category: Edwards, A.M.]]
[[Category: Edwards AM]]
[[Category: Landry, R.]]
[[Category: Landry R]]
[[Category: Park, H.]]
[[Category: Park H]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Shen Y]]
[[Category: Shen, Y.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Tempel W]]
[[Category: Tempel, W.]]
[[Category: Wang J]]
[[Category: Wang, J.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: ADP]]
[[Category: MG]]
[[Category: UNX]]
[[Category: adp]]
[[Category: kinesin]]
[[Category: motor domain]]
[[Category: sgc]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:21:50 2007''

Latest revision as of 12:46, 30 August 2023

Crystal structure of the human KIF2 motor domain in complex with ADPCrystal structure of the human KIF2 motor domain in complex with ADP

Structural highlights

2gry is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.35Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

KIF2A_HUMAN The disease is caused by mutations affecting the gene represented in this entry.

Function

KIF2A_HUMAN Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB, Abraham RT, Jiang W. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell. 2005 Jul;16(7):3187-99. Epub 2005 Apr 20. PMID:15843429 doi:http://dx.doi.org/10.1091/mbc.E05-02-0167
  2. ↑ Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. Mol Biol Cell. 2007 Aug;18(8):2970-9. Epub 2007 May 30. PMID:17538014 doi:http://dx.doi.org/E07-02-0110
  3. ↑ Jang CY, Wong J, Coppinger JA, Seki A, Yates JR 3rd, Fang G. DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. J Cell Biol. 2008 Apr 21;181(2):255-67. doi: 10.1083/jcb.200711032. Epub 2008 Apr, 14. PMID:18411309 doi:http://dx.doi.org/10.1083/jcb.200711032

2gry, resolution 2.35Å

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