1xq7: Difference between revisions

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[[Image:1xq7.png|left|200px]]


{{STRUCTURE_1xq7|  PDB=1xq7  |  SCENE=  }}
==Cyclophilin from Trypanosoma cruzi bound to cyclosporin A==
 
<StructureSection load='1xq7' size='340' side='right'caption='[[1xq7]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
===Cyclophilin from Trypanosoma cruzi bound to cyclosporin A===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1xq7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum] and [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XQ7 FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
[[1xq7]] is a 6 chain structure of [[Cyclophilin]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQ7 OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xq7 OCA], [https://pdbe.org/1xq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xq7 RCSB], [https://www.ebi.ac.uk/pdbsum/1xq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xq7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q4DPB9_TRYCC Q4DPB9_TRYCC] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[RuleBase:RU004223]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xq/1xq7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xq7 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Cyclophilin|Cyclophilin]]
*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
[[Category: Peptidylprolyl isomerase]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Tolypocladium inflatum]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
[[Category: Caruthers, J M.]]
[[Category: Caruthers JM]]
[[Category: Hol, W G.J.]]
[[Category: Hol WGJ]]
[[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]]
[[Category: Cyclophilin]]
[[Category: Cyclophilin-cyclosporin complex]]
[[Category: Cyclosporin some]]
[[Category: Immunosuppressant]]
[[Category: Isomerase-immunosuppressant complex]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Sgpp]]
[[Category: Structural genomic]]
[[Category: Structural genomics of pathogenic protozoa consortium]]

Latest revision as of 09:48, 23 August 2023

Cyclophilin from Trypanosoma cruzi bound to cyclosporin ACyclophilin from Trypanosoma cruzi bound to cyclosporin A

Structural highlights

1xq7 is a 6 chain structure with sequence from Tolypocladium inflatum and Trypanosoma cruzi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.07Å
Ligands:, , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q4DPB9_TRYCC PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[RuleBase:RU004223]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1xq7, resolution 2.07Å

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