1s1g: Difference between revisions
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==Crystal Structure of Kv4.3 T1 Domain== | ==Crystal Structure of Kv4.3 T1 Domain== | ||
<StructureSection load='1s1g' size='340' side='right' caption='[[1s1g]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='1s1g' size='340' side='right'caption='[[1s1g]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1s1g]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1s1g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S1G FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr><td class="sblockLbl"><b>[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1g OCA], [https://pdbe.org/1s1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s1g RCSB], [https://www.ebi.ac.uk/pdbsum/1s1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1g ProSAT]</span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </table> | ||
<table> | |||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN] Note=KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS).<ref>PMID:22457051</ref> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN] Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.<ref>PMID:9843794</ref> <ref>PMID:10200233</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s1/1s1g_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s1/1s1g_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s1g ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1s1g" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Potassium | *[[Potassium channel 3D structures|Potassium channel 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bowlby | [[Category: Large Structures]] | ||
[[Category: Carroll | [[Category: Bowlby MR]] | ||
[[Category: Chanda | [[Category: Carroll KC]] | ||
[[Category: Edris | [[Category: Chanda P]] | ||
[[Category: Jow | [[Category: Edris W]] | ||
[[Category: Katz | [[Category: Jow F]] | ||
[[Category: Kopsco | [[Category: Katz AH]] | ||
[[Category: Lin | [[Category: Kopsco DC]] | ||
[[Category: Lu | [[Category: Lin L]] | ||
[[Category: Malakian | [[Category: Lu Q]] | ||
[[Category: Megules | [[Category: Malakian K]] | ||
[[Category: Mosyak | [[Category: Megules J]] | ||
[[Category: Olland | [[Category: Mosyak L]] | ||
[[Category: Rhodes | [[Category: Olland S]] | ||
[[Category: Scannevin | [[Category: Rhodes KJ]] | ||
[[Category: Somers | [[Category: Scannevin RH]] | ||
[[Category: Stahl | [[Category: Somers W]] | ||
[[Category: Taylor | [[Category: Stahl M]] | ||
[[Category: Wang | [[Category: Taylor M]] | ||
[[Category: Xu | [[Category: Wang KW]] | ||
[[Category: Xu | [[Category: Xu WX]] | ||
[[Category: Xu ZB]] | |||