Pertussis toxin: Difference between revisions
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<StructureSection load='1prt' size='350' side='right' caption='Pertussis toxin (PDB entry [[1prt]])' scene=''> | |||
== Function == | == Function == | ||
'''Pertussis toxin''' (PT) is produced by the bacterium ''Bordetella pertussis'' and is the cause of whooping cough<ref>PMID:15845471</ref>. For additional details see [[Pertussis Toxin-ATP Complex]].<br /> | '''Pertussis toxin''' (PT) is produced by the bacterium ''Bordetella pertussis'' and is the cause of whooping cough<ref>PMID:15845471</ref>. For additional details see [[Pertussis Toxin-ATP Complex]].<br /> | ||
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== Relevance == | == Relevance == | ||
PT is associated with exacerbated host airway response during whooping cough infection and may inhibit host mechanisms of attenuating inflammation of the airways<ref>PMID:23027529</ref>. | PT is associated with exacerbated host airway response during whooping cough infection and may inhibit host mechanisms of attenuating inflammation of the airways<ref>PMID:23027529</ref>. | ||
</StructureSection> | |||
== 3D Structures of Pertussis toxin == | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*Pertussis toxin | |||
**[[1prt]] – BpPT - ''Bordetella pertussis''<br /> | |||
**[[1pto]] – BpPT + galactose<br /> | |||
**[[1bcp]] – BpPT + ATP<br /> | |||
**[[6ro0]] – BpPT 1,2,5 subunits + islet-activating protein S2 + islet-activating protein S3 + islet-activating protein S4<br /> | |||
**[[7ski]] – BpPT subunit 1 + phenanthridine derivative<br /> | |||
**[[7sky]] – BpPT subunit 1 + NAD<br /> | |||
**[[7u6z]] – BpPT subunit 1 (mutant) + NAD<br /> | |||
**[[7sne]] – BpPT subunit 1 + BaAD<br /> | |||
**[[7skk]] – BpPT subunit 1 + ADPR + nicotinamide<br /> | |||
*Pertussis-like toxin | |||
**[[4z9d]] – EcPLT subunit A (mutant) – ''Escherichia coli''<br /> | |||
**[[4z9c]] – EcPLT subunits A,B <br /> | |||
**[[7k7h]] – SaPLT subunits A,B + antibody – ''Salmonella enterica'' – Cryo EM<br /> | |||
*'''Pertactin''' | |||
'' | **[[1dab]] - BpPer<br /> | ||
**[[2iou]] - Per extracellular domain + major tropism determinant - ''Bordetella bronchiseptica''<br /> | |||
}} | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||