Pertussis toxin

Function Pertussis toxin (PT) is produced by the bacterium Bordetella pertussis and is the cause of whooping cough. For additional details see Pertussis Toxin-ATP Complex. Pertactin is another toxin produced by Bordetella. For details see P.69 Pertactin Structure and Function. Relevance PT is associated with exacerbated host airway response during whooping cough infection and may inhibit host mechanisms of attenuating inflammation of the airways.

spinqualitylabelsall models Pertussis toxin (PDB entry 1prt) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Pertussis toxin3D Structures of Pertussis toxin

Updated on 22-August-2023

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• Pertussis toxin
  • 1prt – BpPT - Bordetella pertussis
    
  • 1pto – BpPT + galactose
    
  • 1bcp – BpPT + ATP
    
  • 6ro0 – BpPT 1,2,5 subunits + islet-activating protein S2 + islet-activating protein S3 + islet-activating protein S4
    
  • 7ski – BpPT subunit 1 + phenanthridine derivative
    
  • 7sky – BpPT subunit 1 + NAD
    
  • 7u6z – BpPT subunit 1 (mutant) + NAD
    
  • 7sne – BpPT subunit 1 + BaAD
    
  • 7skk – BpPT subunit 1 + ADPR + nicotinamide
    
• Pertussis-like toxin
  • 4z9d – EcPLT subunit A (mutant) – Escherichia coli
    
  • 4z9c – EcPLT subunits A,B
    
  • 7k7h – SaPLT subunits A,B + antibody – Salmonella enterica – Cryo EM
    
• Pertactin
  • 1dab - BpPer
    
  • 2iou - Per extracellular domain + major tropism determinant - Bordetella bronchiseptica