Pertussis toxin: Difference between revisions

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Jonathan Tringali, Michal Harel

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-{{STRUCTURE_1prt|  PDB=1prt  | SIZE=400| SCENE= |right|CAPTION=Pertussis toxin, [[1prt]] }}
+<StructureSection load='1prt' size='350' side='right' caption='Pertussis toxin (PDB entry [[1prt]])' scene=''>
+== Function ==
+'''Pertussis toxin''' (PT) is produced by the bacterium ''Bordetella pertussis'' and is the cause of whooping cough<ref>PMID:15845471</ref>.  For additional details see [[Pertussis Toxin-ATP Complex]].<br />
+'''Pertactin''' is another toxin produced by ''Bordetella''.  For details see [[P.69 Pertactin Structure and Function]].
+== Relevance ==
+PT is associated with exacerbated host airway response during whooping cough infection and may inhibit host mechanisms of attenuating inflammation of the airways<ref>PMID:23027529</ref>.
+</StructureSection>
+== 3D Structures of Pertussis toxin ==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-'''Pertussis toxin''' (PT) is produced by the bacterium ''Bordetella pertussis'' and is the cause of whooping cough.  For additional details see [[Pertussis Toxin-ATP Complex]].<br />
+*Pertussis toxin
-Pertactin is another toxin produced by "Bordetella".  For details see [[P.69 Pertactin Structure and Function]].
+**[[1prt]] – BpPT - ''Bordetella pertussis''<br />
+**[[1pto]] – BpPT + galactose<br />
+**[[1bcp]] – BpPT + ATP<br />
+**[[6ro0]] – BpPT 1,2,5 subunits + islet-activating protein S2 + islet-activating protein S3 + islet-activating protein S4<br />
+**[[7ski]] – BpPT subunit 1 + phenanthridine derivative<br />
+**[[7sky]] – BpPT subunit 1 + NAD<br />
+**[[7u6z]] – BpPT subunit 1 (mutant) + NAD<br />
+**[[7sne]] – BpPT subunit 1 + BaAD<br />
+**[[7skk]] – BpPT subunit 1 + ADPR + nicotinamide<br />
-== 3D Structures of Pertussis toxin ==
+*Pertussis-like toxin
-[[1prt]] – BpPT - ''Bordetella pertussis''<br />
+**[[4z9d]] – EcPLT subunit A (mutant) – ''Escherichia coli''<br />
-[[1pto]] – BpPT + galactose<br />
+**[[4z9c]] – EcPLT subunits A,B <br />
-[[1bcp]] – BpPT + ATP
+**[[7k7h]] – SaPLT subunits A,B + antibody – ''Salmonella enterica'' – Cryo EM<br />
-'''Pertactin'''
+*'''Pertactin'''
-[[1dab]] - BpPer<br />
+**[[1dab]] - BpPer<br />
-[[2iou]] - Per extracellular domain + major tropism determinant  - ''Bordetella bronchiseptica''<br />
+**[[2iou]] - Per extracellular domain + major tropism determinant  - ''Bordetella bronchiseptica''<br />
+}}
+== References ==
+<references/>
 [[Category:Topic Page]]