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Obscurin: Difference between revisions

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{{STRUCTURE_2yz8| PDB=2yz8 | SIZE=400| SCENE= |right|CAPTION=Human obscurin of 32th IG-like domain residues 3184-3273 [[2yz8]] }}
<StructureSection load='2yz8' size='350' side='right' caption='Human obscurin of 32th IG-like domain residues 3184-3273 (PDB entry [[2yz8]])' scene=''>
 
== Function ==
== Function ==
'''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles.  Other giant proteins in the family include titin and nebulin.  It is a multidomain protein containing adhesion modules and signaling domains.  These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.
'''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles.  Other giant proteins in the family include titin and nebulin.  It is a multidomain protein containing adhesion modules and signaling domains.  These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.
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== Disease ==
== Disease ==
Mutations of Obs are found in hypertrophy cardiomyopathy<ref>PMID:17716621</ref>.
Mutations of Obs are found in hypertrophy cardiomyopathy<ref>PMID:17716621</ref>.
 
</StructureSection>
==3D structures of obscurin==
==3D structures of obscurin==


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**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />
**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />
**[[2dm7]] - hObs 14th Ig domain residues 1157-1251 – NMR<br />
**[[2eo1]] - hObs Ig domain residues 69-163 – NMR<br />
**[[7r68]] - hObs 12th Ig domain residues 1071-1162 – NMR<br />
**[[2dm7]], [[7r67]] - hObs 13th Ig domain residues 1161-1254 – NMR<br />
**[[2gqh]] - hObs 15th Ig domain residues 1253-1346 – NMR<br />
**[[2gqh]] - hObs 15th Ig domain residues 1253-1346 – NMR<br />
**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />
**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />
**[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR />
**[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR />
**[[2dku]] - hObs Ig domain residues 2915-3004 – NMR<br />
**[[2dku]] - hObs 3rd Ig domain residues 2915-3004 – NMR<br />
**[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />
**[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />
**[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br />
**[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br />
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**[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />
**[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />
**[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />
**[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />
**[[6mg9]] - hObs 57th Ig domain residues 4247-4338 – NMR<br />
**[[2mwc]], [[4rsv]] - hObs 58th Ig domain residues 4337-4429 – NMR<br />
**[[5tzm]] - hObs 59th Ig domain residues 4946-5036 <br />
**[[2n56]] - hObs 59th Ig domain residues 4430-4524 – NMR<br />
**[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />
**[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />
**[[8ak2]] - DmObs kinase domain residues 3186-3480 – ''Drosophila melanogaster''<br />
**[[8ak3]] - DmObs kinase domain + ADP<br />


*Obscurin-like protein 1
*Obscurin-like protein 1


**[[5fm5]] - hObsL 3rd Ig domain residues 251-339 + myomesin-1<br />
**[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR />
**[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR />
**[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR />
**[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR />
**[[3knb]], [[2wp3]], [[2wwm]], [[4c4k]] – hObs N terminal residues 1-105 + titin M10 domain <br />
**[[2lvc]] - hObsL 6th Ig domain residues 805-892 – NMR<br />
**[[4uow]] - hObs residues 26829-26925+ titin M10 domain<br />
**[[2lu7]] - hObsL 11th Ig domain residues 1277-1357 – NMR<br />
**[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br />
**[[3knb]], [[2wp3]], [[2wwm]], [[4c4k]] – hObsL N terminal residues 1-105 + titin M10 domain <br />
**[[2wwk]] – hObsL N terminal residues (mutant) + titin M10 domain<br />
**[[4uow]] - hObsL residues 26829-26925 + titin M10 domain<br />
 
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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