Obscurin: Difference between revisions

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Michal Harel, Alexander Berchansky

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-{{STRUCTURE_2wwm|  PDB=2wwm  | SIZE=400| SCENE= |right|CAPTION=Obscurin N terminal complex with titin M10 domain, [[2wwm]] }}
+<StructureSection load='2yz8' size='350' side='right' caption='Human obscurin of 32th IG-like domain residues 3184-3273 (PDB entry [[2yz8]])' scene=''>
+== Function ==
+'''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles.  Other giant proteins in the family include titin and nebulin.  It is a multidomain protein containing adhesion modules and signaling domains.  These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.
+Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane.  It associates with the contractile apparatus via binding to titin and sarcomeric myosin.  Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril<ref>PMID:17012262</ref>.
-<!--
+For more details see [[Group:MUZIC:Obscurin]].
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-'''Obscurin''' (Obs) is a giant protein expressed in striated muscles.  It is a multidomain protein containing adhesion modules and signaling domains.
+== Disease ==
+Mutations of Obs are found in hypertrophy cardiomyopathy<ref>PMID:17716621</ref>.
+</StructureSection>
 ==3D structures of obscurin==
-[[3knb, [[2wp3]], [[2wwm]] – hObs N terminal residues 1-105 + titin M10 domain – human<br />
+{{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br />
+{{#tree:id=OrganizedByTopic|openlevels=0|
-[[2e7b]] - hObs Ig domain residues 8-97 – NMR<BR />
-[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />
-[[2edf]] - hObs Ig domain residues 2826-2915 – NMR<BR />
-[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />
-[[2yz8]] - hObs Ig domain residues 3184-3273 <br />
-[[2edr]] - hObs Ig domain residues 3361-3449 – NMR<BR />
-[[2edt]] - hObs Ig domain residues 3449-3537 – NMR<BR />
-[[2edw]] - hObs I-set domain residues 3537-3630 – NMR<BR />
-[[2edh]] – hObs PDZ domain residues 3614-3713 – NMR<BR />
-[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />
-[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />
-[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />
-'''Obscurin-like protein 1'''
+*Obscurin
-[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR />
+**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />
-[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR />
+**[[2eo1]] - hObs Ig domain residues 69-163 – NMR<br />
+**[[7r68]] - hObs 12th Ig domain residues 1071-1162 – NMR<br />
+**[[2dm7]], [[7r67]] - hObs 13th Ig domain residues 1161-1254 – NMR<br />
+**[[2gqh]] - hObs 15th Ig domain residues 1253-1346 – NMR<br />
+**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />
+**[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR />
+**[[2dku]] - hObs 3rd Ig domain residues 2915-3004 – NMR<br />
+**[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />
+**[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br />
+**[[2edr]] - hObs Ig domain residues 3361-3449 – NMR<BR />
+**[[2edt]] - hObs Ig domain residues 3449-3537 – NMR<BR />
+**[[2edw]] - hObs I-set domain residues 3537-3630 – NMR<BR />
+**[[2edh]] – hObs PDZ domain residues 3614-3713 – NMR<BR />
+**[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />
+**[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />
+**[[6mg9]] - hObs 57th Ig domain residues 4247-4338 – NMR<br />
+**[[2mwc]], [[4rsv]] - hObs 58th Ig domain residues 4337-4429 – NMR<br />
+**[[5tzm]] - hObs 59th Ig domain residues 4946-5036 <br />
+**[[2n56]] - hObs 59th Ig domain residues 4430-4524 – NMR<br />
+**[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />
+**[[8ak2]] - DmObs kinase domain residues 3186-3480 – ''Drosophila melanogaster''<br />
+**[[8ak3]] - DmObs kinase domain + ADP<br />
+*Obscurin-like protein 1
+**[[5fm5]] - hObsL 3rd Ig domain residues 251-339 + myomesin-1<br />
+**[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR />
+**[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR />
+**[[2lvc]] - hObsL 6th Ig domain residues 805-892 – NMR<br />
+**[[2lu7]] - hObsL 11th Ig domain residues 1277-1357 – NMR<br />
+**[[3knb]], [[2wp3]], [[2wwm]], [[4c4k]] – hObsL N terminal residues 1-105 + titin M10 domain <br />
+**[[2wwk]] – hObsL N terminal residues (mutant) + titin M10 domain<br />
+**[[4uow]] - hObsL residues 26829-26925 + titin M10 domain<br />
+}}
+== References ==
+<references/>
 [[Category:Topic Page]]