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New page: left|200px<br /><applet load="2rkc" size="350" color="white" frame="true" align="right" spinBox="true" caption="2rkc, resolution 2.70Å" /> '''Crystal structure of... |
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== | ==Crystal structure of the measles virus hemagglutinin== | ||
<StructureSection load='2rkc' size='340' side='right'caption='[[2rkc]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
[[ | == Structural highlights == | ||
[[ | <table><tr><td colspan='2'>[[2rkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_morbillivirus Measles morbillivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RKC FirstGlance]. <br> | ||
[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rkc OCA], [https://pdbe.org/2rkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rkc RCSB], [https://www.ebi.ac.uk/pdbsum/2rkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rkc ProSAT]</span></td></tr> | ||
[ | </table> | ||
[ | == Function == | ||
[https://www.uniprot.org/uniprot/HEMA_MEASE HEMA_MEASE] Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.<ref>PMID:9811778</ref> | |||
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==See Also== | |||
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Measles morbillivirus]] | |||
[[Category: Colf LA]] | |||
[[Category: Garcia KC]] | |||
[[Category: Juo ZS]] | |||
Latest revision as of 16:11, 26 July 2023
Crystal structure of the measles virus hemagglutininCrystal structure of the measles virus hemagglutinin
Structural highlights
FunctionHEMA_MEASE Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.[1] See AlsoReferences |
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