Nuclear transcription factor Y: Difference between revisions

Latest revision as of 13:26, 20 July 2023

Function

Nuclear transcription factor Y (NFY) binds to a CCAAT sequence of gene promoters. NFY contains 3 subunits while subunit α binds the promoter box sequence^[1]. See details in NF-Y Transcription Factor.

Relevance

NFY is a regulatory factor for many genes which are overexpressed in many kinds of cancer^[2].

Structural highlights

(PDB code 4awl). The ^[3].

Human nuclear transcription factor Y subunit α (cyan), subunit β (green) and subunit γ (pink) complex with HSP70 promoter DNA fragment (PDB code 4awl)

Drag the structure with the mouse to rotate

3D Structures of nuclear transcription factor Y3D Structures of nuclear transcription factor Y

Updated on 20-July-2023

1n1j, 4csr, 7ah8 – hNFY β+γ subunits - human
6qmp, 6qmq, 6qms – hNFY α peptide+β+γ subunits
4awl – hNFY α+β+γ subunits + promoter DNA
5g49 – AtNFY β6+γ3 subunits – Arabidopsis thaliana
6r0m, 6r0n – AtNFY b2+c3 subunits histone-fold domain
6r2v – AtNFY a6+b2+c3 subunits + DNA
7cvq – AtNFY b2+c3 subunits + DNA
7cvo – AtNFY b2+b3+c3+c4 subunits + DNA
7c9p – rNFY b11+c2 subunits – rice
7c9o – rNFY b11+c2 subunits + zinc finger protein HD1 + DNA
6r0m, 6r0n – AtNFY b2+c3 subunits histone-fold domain
6r0l – rNFY c7 subunit + OsGhd8

ReferencesReferences

↑ Maity SN, de Crombrugghe B. Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci. 1998 May;23(5):174-8. PMID:9612081
↑ Bargou RC, Jurchott K, Wagener C, Bergmann S, Metzner S, Bommert K, Mapara MY, Winzer KJ, Dietel M, Dorken B, Royer HD. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med. 1997 Apr;3(4):447-50. PMID:9095180
↑ Nardini M, Gnesutta N, Donati G, Gatta R, Forni C, Fossati A, Vonrhein C, Moras D, Romier C, Bolognesi M, Mantovani R. Sequence-Specific Transcription Factor NF-Y Displays Histone-like DNA Binding and H2B-like Ubiquitination. Cell. 2013 Jan 17;152(1-2):132-43. doi: 10.1016/j.cell.2012.11.047. PMID:23332751 doi:http://dx.doi.org/10.1016/j.cell.2012.11.047

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Maity SN, de Crombrugghe B. Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci. 1998 May;23(5):174-8. PMID:9612081

[2] Bargou RC, Jurchott K, Wagener C, Bergmann S, Metzner S, Bommert K, Mapara MY, Winzer KJ, Dietel M, Dorken B, Royer HD. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med. 1997 Apr;3(4):447-50. PMID:9095180

[3] Nardini M, Gnesutta N, Donati G, Gatta R, Forni C, Fossati A, Vonrhein C, Moras D, Romier C, Bolognesi M, Mantovani R. Sequence-Specific Transcription Factor NF-Y Displays Histone-like DNA Binding and H2B-like Ubiquitination. Cell. 2013 Jan 17;152(1-2):132-43. doi: 10.1016/j.cell.2012.11.047. PMID:23332751 doi:http://dx.doi.org/10.1016/j.cell.2012.11.047

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@@ Line 1: / Line 1: @@
-<StructureSection load='4awl' size='340' side='right' caption='Human nuclear transcription factor Y subunit β (grey) and subunit γ(green) (PDB code [[1n1j]])' scene=''>
+<StructureSection load='' size='350' side='right' caption='Human nuclear transcription factor Y subunit α (cyan), subunit β (green) and subunit γ (pink) complex with HSP70 promoter DNA fragment (PDB code [[4awl]])' scene='72/725371/Cv/1'>
 == Function ==
 '''Nuclear transcription factor Y''' (NFY) binds to a CCAAT sequence of gene promoters.  NFY contains 3 subunits while subunit α binds the promoter box sequence<ref>PMID:9612081</ref>.  See details in [[NF-Y Transcription Factor]].
 == Relevance ==
+NFY is a regulatory factor for many genes which are overexpressed in many kinds of cancer<ref>PMID:9095180</ref>.
-NFY is a regulatory factor for many genes which are overexpressed in many kinds of cancer<ref>PMID:9095180</ref>.
+== Structural highlights ==
+<scene name='72/725371/Cv/5'>Human nuclear transcription factor Y subunit α, subunit β, subunit γ with HSP70 promoter fragment</scene> (PDB code [[4awl]]). The <scene name='72/725371/Cv/6'>interaction of NFY with the promoter CCAAT sequence, involves an insertion of an NFY helix into the minor groove of the DNA</scene><ref>PMID:23332751</ref>.
 </StructureSection>
@@ Line 16: / Line 16: @@
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1n1j]], [[4csr]] – hNFY β+γ subunits - human<br />
+[[1n1j]], [[4csr]], [[7ah8]] – hNFY β+γ subunits - human<br />
+[[6qmp]], [[6qmq]], [[6qms]] – hNFY α peptide+β+γ subunits <br />
 [[4awl]] – hNFY α+β+γ subunits + promoter DNA<br />
+[[5g49]] – AtNFY β6+γ3 subunits – ''Arabidopsis thaliana''<br />
+[[6r0m]], [[6r0n]] – AtNFY b2+c3 subunits histone-fold domain<br />
+[[6r2v]] – AtNFY a6+b2+c3 subunits + DNA<br />
+[[7cvq]] – AtNFY b2+c3 subunits + DNA<br />
+[[7cvo]] – AtNFY b2+b3+c3+c4 subunits + DNA<br />
+[[7c9p]] – rNFY b11+c2 subunits – rice<br />
+[[7c9o]] – rNFY b11+c2 subunits + zinc finger protein HD1 + DNA<br />
+[[6r0m]], [[6r0n]] – AtNFY b2+c3 subunits histone-fold domain<br />
+[[6r0l]] – rNFY c7 subunit + OsGhd8 <br />
 == References ==
 <references/>
+[[Category:Topic Page]]