Muscle LIM protein: Difference between revisions
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<StructureSection load='' size='350' side='right' caption='Human muscle LIM protein 3 LiM domain complex with Zn+2 ions, NMR structure (PDB entry [[1x4l]])' scene=''> | <StructureSection load='1x4l' size='350' side='right' caption='Human muscle LIM protein 3 LiM domain complex with Zn+2 ions, NMR structure (PDB entry [[1x4l]])' scene=''> | ||
== Function == | == Function == | ||
'''Muscle LIM protein''' (MLP) is a nuclear regulator of myogenic differentiation. It may act as an integrator of protein assembly of the actin-based cytoskeleton<ref>PMID:9234731</ref>. For more details see [[Group:MUZIC:MLP]] and [[MLP]]. | '''Muscle LIM protein''' (MLP) is a nuclear regulator of myogenic differentiation. It may act as an integrator of protein assembly of the actin-based cytoskeleton<ref>PMID:9234731</ref>. For more details see [[Group:MUZIC:MLP]] and [[MLP]]. | ||
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[[1wyh]], [[2d8z]] – hLMP 2 LIM domain – human – NMR<BR /> | [[1wyh]], [[2d8z]] – hLMP 2 LIM domain – human – NMR<BR /> | ||
[[1x4k]], [[1x4l]], [[2ehe]] - hLMP 3 LIM domain – NMR<BR /> | [[1x4k]], [[1x4l]], [[2ehe]], [[2miu]] - hLMP 3 LIM domain – NMR<BR /> | ||
[[2cuq]] – hLMP2 2 LIM domain – NMR<br /> | |||
[[1x63]], [[2cup]], [[2cur]], [[2egq]] - hLMP 1 LIM domain – NMR<BR /> | [[1x63]], [[2cup]], [[2cur]], [[2egq]] - hLMP 1 LIM domain – NMR<BR /> | ||
[[2o10]] - hLMP N terminal – NMR<BR /> | [[2o10]] - hLMP N terminal – NMR<BR /> | ||
Latest revision as of 09:36, 10 July 2023
FunctionMuscle LIM protein (MLP) is a nuclear regulator of myogenic differentiation. It may act as an integrator of protein assembly of the actin-based cytoskeleton[1]. For more details see Group:MUZIC:MLP and MLP. DiseaseMutations in MLP are seen in cases of cardiomyopathy[2]. |
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3D structures of muscle LIM protein3D structures of muscle LIM protein
Updated on 10-July-2023
1wyh, 2d8z – hLMP 2 LIM domain – human – NMR
1x4k, 1x4l, 2ehe, 2miu - hLMP 3 LIM domain – NMR
2cuq – hLMP2 2 LIM domain – NMR
1x63, 2cup, 2cur, 2egq - hLMP 1 LIM domain – NMR
2o10 - hLMP N terminal – NMR
2o13 - hLMP C terminal – NMR
ReferencesReferences
- ↑ Kong Y, Flick MJ, Kudla AJ, Konieczny SF. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol Cell Biol. 1997 Aug;17(8):4750-60. PMID:9234731
- ↑ Geier C, Perrot A, Ozcelik C, Binner P, Counsell D, Hoffmann K, Pilz B, Martiniak Y, Gehmlich K, van der Ven PF, Furst DO, Vornwald A, von Hodenberg E, Nurnberg P, Scheffold T, Dietz R, Osterziel KJ. Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy. Circulation. 2003 Mar 18;107(10):1390-5. PMID:12642359