2miu

From Proteopedia
Jump to navigation Jump to search

Structure of FHL2 LIM adaptor and its Interaction with SkiStructure of FHL2 LIM adaptor and its Interaction with Ski

Structural highlights

2miu is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FHL2_HUMAN May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.[1] [2] [3]

See Also

References

  1. ↑ Yang Y, Hou H, Haller EM, Nicosia SV, Bai W. Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO J. 2005 Mar 9;24(5):1021-32. Epub 2005 Feb 3. PMID:15692560 doi:10.1038/sj.emboj.7600570
  2. ↑ Paul C, Lacroix M, Iankova I, Julien E, Schafer BW, Labalette C, Wei Y, Le Cam A, Le Cam L, Sardet C. The LIM-only protein FHL2 is a negative regulator of E4F1. Oncogene. 2006 Sep 7;25(40):5475-84. Epub 2006 May 1. PMID:16652157 doi:http://dx.doi.org/1209567
  3. ↑ Siamakpour-Reihani S, Argiros HJ, Wilmeth LJ, Haas LL, Peterson TA, Johnson DL, Shuster CB, Lyons BA. The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner. J Mol Recognit. 2009 Jan-Feb;22(1):9-17. doi: 10.1002/jmr.916. PMID:18853468 doi:http://dx.doi.org/10.1002/jmr.916
Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2miu&oldid=4152925"