Muscle LIM protein: Difference between revisions

Latest revision as of 09:36, 10 July 2023

Function

Muscle LIM protein (MLP) is a nuclear regulator of myogenic differentiation. It may act as an integrator of protein assembly of the actin-based cytoskeleton^[1]. For more details see Group:MUZIC:MLP and MLP.

Disease

Mutations in MLP are seen in cases of cardiomyopathy^[2].

Human muscle LIM protein 3 LiM domain complex with Zn+2 ions, NMR structure (PDB entry 1x4l)

Drag the structure with the mouse to rotate

3D structures of muscle LIM protein3D structures of muscle LIM protein

Updated on 10-July-2023

1wyh, 2d8z – hLMP 2 LIM domain – human – NMR
1x4k, 1x4l, 2ehe, 2miu - hLMP 3 LIM domain – NMR
2cuq – hLMP2 2 LIM domain – NMR
1x63, 2cup, 2cur, 2egq - hLMP 1 LIM domain – NMR
2o10 - hLMP N terminal – NMR
2o13 - hLMP C terminal – NMR

ReferencesReferences

↑ Kong Y, Flick MJ, Kudla AJ, Konieczny SF. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol Cell Biol. 1997 Aug;17(8):4750-60. PMID:9234731
↑ Geier C, Perrot A, Ozcelik C, Binner P, Counsell D, Hoffmann K, Pilz B, Martiniak Y, Gehmlich K, van der Ven PF, Furst DO, Vornwald A, von Hodenberg E, Nurnberg P, Scheffold T, Dietz R, Osterziel KJ. Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy. Circulation. 2003 Mar 18;107(10):1390-5. PMID:12642359

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

[1] Kong Y, Flick MJ, Kudla AJ, Konieczny SF. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol Cell Biol. 1997 Aug;17(8):4750-60. PMID:9234731

[2] Geier C, Perrot A, Ozcelik C, Binner P, Counsell D, Hoffmann K, Pilz B, Martiniak Y, Gehmlich K, van der Ven PF, Furst DO, Vornwald A, von Hodenberg E, Nurnberg P, Scheffold T, Dietz R, Osterziel KJ. Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy. Circulation. 2003 Mar 18;107(10):1390-5. PMID:12642359

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_1x4l|  PDB=1x4l  | SIZE=350| SCENE= |right|CAPTION=Human muscle LIM protein 3 LiM domain complex with Zn+2 ions, NMR structure, [[1x4l]] }}
+<StructureSection load='1x4l' size='350' side='right' caption='Human muscle LIM protein 3 LiM domain complex with Zn+2 ions, NMR structure (PDB entry [[1x4l]])' scene=''>
+== Function ==
+'''Muscle LIM protein''' (MLP) is a nuclear regulator of myogenic differentiation.  It may act as an integrator of protein assembly of the actin-based cytoskeleton<ref>PMID:9234731</ref>.  For more details see [[Group:MUZIC:MLP]] and [[MLP]].
-'''Muscle LIM protein''' (MLP) is a nuclear regulator of myogenic differentiation.  It may act as an integrator of protein assembly of the actin-based cytoskeleton.  Mutations in MLP are seen in cases of cardiomyopathy.  For more details see [[Group:MUZIC:MLP]], [[MLP]].
+== Disease ==
+Mutations in MLP are seen in cases of cardiomyopathy<ref>PMID:12642359</ref>.
+</StructureSection>
+==3D structures of muscle LIM protein==
-==3D structures of muscle LIM protein==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 [[1wyh]], [[2d8z]] – hLMP 2 LIM domain – human – NMR<BR />
-[[1x4k]], [[1x4l]], [[2ehe]] - hLMP 3 LIM domain – NMR<BR />
+[[1x4k]], [[1x4l]], [[2ehe]], [[2miu]] - hLMP 3 LIM domain – NMR<BR />
+[[2cuq]] – hLMP2 2 LIM domain – NMR<br />
 [[1x63]], [[2cup]], [[2cur]], [[2egq]] - hLMP 1 LIM domain – NMR<BR />
 [[2o10]] - hLMP N terminal – NMR<BR />
 [[2o13]] - hLMP C terminal – NMR<BR />
+== References ==
+<references/>
+[[Category:Topic Page]]