5e26: Difference between revisions
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<StructureSection load='5e26' size='340' side='right'caption='[[5e26]], [[Resolution|resolution]] 2.14Å' scene=''> | <StructureSection load='5e26' size='340' side='right'caption='[[5e26]], [[Resolution|resolution]] 2.14Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5e26]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5e26]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E26 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e26 OCA], [https://pdbe.org/5e26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e26 RCSB], [https://www.ebi.ac.uk/pdbsum/5e26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e26 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/PANK2_HUMAN PANK2_HUMAN] Atypical pantothenate kinase-associated neurodegeneration;Classic pantothenate kinase-associated neurodegeneration. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PANK2_HUMAN PANK2_HUMAN] May be the master regulator of the CoA biosynthesis. | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith CH]] | |||
[[Category: Arrowsmith | [[Category: BROWN PJ]] | ||
[[Category: BROWN | [[Category: Bountra C]] | ||
[[Category: Bountra | [[Category: CHENG C]] | ||
[[Category: CHENG | [[Category: DONG A]] | ||
[[Category: DONG | [[Category: Edwards AM]] | ||
[[Category: Edwards | [[Category: HONG BS]] | ||
[[Category: HONG | [[Category: HUTCHINSON A]] | ||
[[Category: HUTCHINSON | [[Category: LOPPNAU P]] | ||
[[Category: LOPPNAU | [[Category: RAVICHANDRAN M]] | ||
[[Category: RAVICHANDRAN | [[Category: SEITOVA A]] | ||
[[Category: SEITOVA | [[Category: TEMPEL W]] | ||
[[Category: TEMPEL | |||
Latest revision as of 09:10, 5 July 2023
Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphateCrystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate
Structural highlights
DiseasePANK2_HUMAN Atypical pantothenate kinase-associated neurodegeneration;Classic pantothenate kinase-associated neurodegeneration. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. FunctionPANK2_HUMAN May be the master regulator of the CoA biosynthesis. See Also |
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