5e26: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5e26 is ON HOLD
+==Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate==
+<StructureSection load='5e26' size='340' side='right'caption='[[5e26]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5e26]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E26 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e26 OCA], [https://pdbe.org/5e26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e26 RCSB], [https://www.ebi.ac.uk/pdbsum/5e26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e26 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PANK2_HUMAN PANK2_HUMAN] Atypical pantothenate kinase-associated neurodegeneration;Classic pantothenate kinase-associated neurodegeneration. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/PANK2_HUMAN PANK2_HUMAN] May be the master regulator of the CoA biosynthesis.
-Authors: DONG, A., LOPPNAU, P., RAVICHANDRAN, M., CHENG, C., TEMPEL, W., SEITOVA, A., HUTCHINSON, A., HONG, B.S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., Structural Genomics Consortium (SGC)
+==See Also==
+*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
-Description: Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Hutchinson, A]]
+[[Category: Homo sapiens]]
-[[Category: Dong, A]]
+[[Category: Large Structures]]
-[[Category: Ravichandran, M]]
+[[Category: Arrowsmith CH]]
-[[Category: Hong, B.S]]
+[[Category: BROWN PJ]]
-[[Category: Cheng, C]]
+[[Category: Bountra C]]
-[[Category: Bountra, C]]
+[[Category: CHENG C]]
-[[Category: Tempel, W]]
+[[Category: DONG A]]
-[[Category: Loppnau, P]]
+[[Category: Edwards AM]]
-[[Category: Arrowsmith, C.H]]
+[[Category: HONG BS]]
-[[Category: Seitova, A]]
+[[Category: HUTCHINSON A]]
-[[Category: Brown, P.J]]
+[[Category: LOPPNAU P]]
-[[Category: Edwards, A.M]]
+[[Category: RAVICHANDRAN M]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: SEITOVA A]]
+[[Category: TEMPEL W]]