Ire1: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='3lj0' size='400' side='right' caption='Structure of yeast Ire1 cytoplasmic domain dimer complex with quercetin, ADP (stick model), Ca+2 and Sr+2 ions (PDB entry [[3lj0]])' scene=''>
+<StructureSection load='3lj0' size='400' side='right' caption='Structure of yeast Ire1 cytoplasmic domain dimer complex with quercetin, ADP, Ca+2 and Sr+2 ions (PDB entry [[3lj0]])' scene='51/516469/Cv/1'>
 == Function ==
-'''Ire1''' is a serine/threonine protein kinase/endoribonuclease.  It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals<ref>PMID:11034898</ref>.  The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis.  The kinase domain of Ire1 is required for activation of the endoribonuclase domain.  Ire1 senses unfolded proteins causing its auto-activation.
+'''Ire1''' or '''serine/threonine protein kinase/endoribonuclease Ire1'''.  It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals<ref>PMID:11034898</ref>.  The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis.  The kinase domain of Ire1 is required for activation of the endoribonuclase domain.  Ire1 senses unfolded proteins causing its auto-activation.
 == Structural highlights ==
-Yeast Ire1 structure contains 3 phosphorylated residues: 2 Ser and a Thr.  Iew1 shows a different binding site for ADP and for quercetin.  Quercetin is a powerful activator of Ire1.  Ire1 binds 2 molecules of quercetin at its dimer interface<ref>PMID:23880584</ref>.
+Yeast Ire1 structure contains 3 phosphorylated residues: <scene name='51/516469/Cv/9'>2 Ser and a Thr</scene>.  Ire1 shows a different <scene name='51/516469/Cv/10'>binding site for ADP</scene> and for quercetin.  Quercetin is a powerful activator of Ire1.  <scene name='51/516469/Cv/11'>Ire1 binds 2 molecules of quercetin at its dimer interface</scene><ref>PMID:23880584</ref>.
 ==3D structures of Ire1==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[2hz6]] – hIre1 N terminal (mutant) – human<br />
+[[2hz6]], [[6shc]] – hIre1 luminal domain 24-419 (mutant) – human<br />
+[[4z7g]], [[5hgi]], [[6w3b]], [[6w3c]] – hIre1 cytoplasmic domain 547-977<br />
+[[3p23]], [[4yzd]] - hIre1 cytoplasmic domain + ADP<br />
+[[4u6r]], [[4yz9]], [[4z7h]], [[6urc]], [[6hv0]], [[6hx1]], [[6w39]], [[6w3a]], [[6w3e]], [[6w3k]], [[6xdb]], [[6xdd]], [[6xdf]], [[7bmk]] – hIre1 cytoplasmic domain + inhibitor <br />
+[[4yzc]] – hIre1 cytoplasmic domain + satuorosporine <br />
+[[4pl3]], [[4pl4]], [[4pl5]] – mIre1 cytoplasmic domain (mutant) + inhibitor – mouse<br />
 [[2rio]], [[3fbv]], [[3sdm]] – yIre1 cytoplasmic domain – yeast<br />
 [[3sdj]] - yIre1 cytoplasmic domain (mutant) <br />
-[[2bei]] – yIre1 lumenal domain + peptide<br />
+[[2be1]] – yIre1 lumenal domain + peptide<br />
 [[3lj0]] -  yIre1 cytoplasmic domain + quercetin + ADP<br />
 [[3lj1]], [[3lj2]] - yIre1 cytoplasmic domain + inhibitor<br />
-[[3p23]] - hIre1 cytoplasmic domain + ADP
 == References ==
 <references/>
 [[Category:Topic Page]]