Ire1

<StructureSection load='3lj0' size='400' side='right' caption='Structure of yeast Ire1 cytoplasmic domain dimer complex with quercetin, ADP, Ca+2 and Sr+2 ions (PDB entry 3lj0)' scene='51/516469/Cv/1'>

FunctionFunction

Ire1 or serine/threonine protein kinase/endoribonuclease Ire1. It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis. The kinase domain of Ire1 is required for activation of the endoribonuclase domain. Ire1 senses unfolded proteins causing its auto-activation.

Structural highlightsStructural highlights

Yeast Ire1 structure contains 3 phosphorylated residues: . Ire1 shows a different and for quercetin. Quercetin is a powerful activator of Ire1. .

3D structures of Ire13D structures of Ire1

Updated on 12-June-2023

2hz6, 6shc – hIre1 luminal domain 24-419 (mutant) – human
4z7g, 5hgi, 6w3b, 6w3c – hIre1 cytoplasmic domain 547-977
3p23, 4yzd - hIre1 cytoplasmic domain + ADP
4u6r, 4yz9, 4z7h, 6urc, 6hv0, 6hx1, 6w39, 6w3a, 6w3e, 6w3k, 6xdb, 6xdd, 6xdf, 7bmk – hIre1 cytoplasmic domain + inhibitor
4yzc – hIre1 cytoplasmic domain + satuorosporine
4pl3, 4pl4, 4pl5 – mIre1 cytoplasmic domain (mutant) + inhibitor – mouse
2rio, 3fbv, 3sdm – yIre1 cytoplasmic domain – yeast
3sdj - yIre1 cytoplasmic domain (mutant)
2be1 – yIre1 lumenal domain + peptide
3lj0 - yIre1 cytoplasmic domain + quercetin + ADP
3lj1, 3lj2 - yIre1 cytoplasmic domain + inhibitor