Stimulator of interferon genes protein: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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 == Structural highlights ==
-The biological assembly of UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase is <scene name='87/873780/Cv/4'>homotrimer</scene> (PDB code [[6uec]]). The 3D structure of LpxD complex with a ligand shows the binding site to be situated at <scene name='87/873780/Cv/6'>the interface of the crystallographic dimer</scene>. There are extensive polar interactions with LpxD as well as hydrogen bonds<ref>PMID:31664082</ref>.
+The 3D structure of the complex between human STING and cyclic GMP-AMP shows the dinucleotide bound by the symmetric dimer of STING.  The U-shaped cleft between the 2 subunits makes numerous interactions with the U-shaped ligand.  A Tyr residue from each monomer stacks against each of the purine moieties while an Arg residue from each monomer forms hydrogen bonds to the dinucleotide <ref>PMID:23910378</ref>.
 </StructureSection>
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 *Stimulator of interferon genes protein complex
-**[[4ef4]], [[4emt]], [[4emu]], [[4f5y]], [[4f9g]], [[6rm0]], [[6s86]] – hSTING C-di-GMP-binding domain + GMP derivative<br />
+**[[4ef4]], [[4emt]], [[4emu]], [[4f5y]], [[4f9g]], [[6s86]] – hSTING C-di-GMP-binding domain + GMP derivative<br />
 **[[4f5d]] – hSTING C-di-GMP-binding domain (mutant) + GMP derivative <br />
 **[[6cff]], [[6cy7]] – hSTING C-di-GMP-binding domain + AMP derivative <br />