Ecotin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-{{STRUCTURE_1id5|  PDB=1id5  | SIZE=400| SCENE= |right|CAPTION=A monomer of the dimeric E. coli ecotin (gold) complex with thrombin heavy chain (pink) and light chain (aqua), protease inhibitor and Ca+2 ion [[1id5]] }}
+<StructureSection load='1id5' size='400' side='right' scene='46/465444/Cv/2' caption='The dimeric E. coli ecotin (yellow) complex with thrombin heavy chain (cyan) and light chain (magenta) and Ca+2 ion (green) [[1id5]]'>
-'''Ecotin''' (ECO) is a serine protease inhibitor found in the periplasm of E. coli.  It is a potent anti and a reversible tight-binding inhibitor of human factor Xa.
+'''Ecotin''' (ECO) is a serine protease inhibitor found in the periplasm of ''E. coli''.  It is a potent anti and a reversible tight-binding inhibitor of human factor Xa.<ref>PMID:14705961</ref>
-{{TOC limit|limit=2}}
+<scene name='46/465444/Cv/7'>The dimeric E. coli ecotin</scene> with <scene name='46/465444/Cv/8'>thrombin heavy and light chains</scene>.
+<scene name='46/465444/Cv/9'>Ca+2 ion coordination site</scene> in thrombin heavy chain ([[1id5]]).<ref>PMID:11513582</ref> Water molecules shown as red spheres.
+</StructureSection>
 == 3D Structures of Ecotin ==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-[[1ecy]], [[1ecz]] – ECO - ''Escherichia coli''<br />
+*Ecotin
-[[1ifg]] - ECO (mutant)
-'''Ecotin complex with protein'''
+**[[1ecy]], [[1ecz]] – ECO - ''Escherichia coli''<br />
+**[[1ifg]] - ECO (mutant)
-[[1slu]], [[1slv]], [[1slw]], [[1slx]], [[1ezs]], [[1ezu]] – ECO (mutant) + anionic trypsin (mutant) <br />
+*Ecotin complex with protein
-[[1azz]] – ECO + collagenase<br />
-[[1id5]] - ECO (mutant) + thrombin<br />
-[[1n8o]], [[1y6t]], [[2y6t]] - ECO + chymotrypsin<br />
-[[1p0s]] - ECO (mutant) + factor Xa<br />
-[[1xx9]] - ECO (mutant) + factor Xi<br />
-[[1xxd]], [[1xxf]] - ECO (mutant) + factor Xi (mutant) <br />
-[[1fi8]] - ECO (mutant) + granzyme B<br />
-[[4iw4]] – ECO + mannan-binding lectin serine protease<br />
+**[[1slu]], [[1slv]], [[1slw]], [[1slx]], [[1ezs]], [[1ezu]], [[4niy]] – ECO (mutant) + anionic trypsin (mutant) <br />
+**[[1azz]] – ECO + collagenase<br />
+**[[1id5]] - ECO (mutant) + thrombin<br />
+**[[1n8o]], [[1y6t]], [[2y6t]] - ECO + chymotrypsin<br />
+**[[1p0s]] - ECO (mutant) + factor Xa<br />
+**[[1xx9]] - ECO (mutant) + factor Xi<br />
+**[[1xxd]], [[1xxf]] - ECO (mutant) + factor Xi (mutant) <br />
+**[[1fi8]] - ECO (mutant) + granzyme B<br />
+**[[4iw4]] – ECO + mannan-binding lectin serine protease<br />
+**[[7cbk]] – ECO + elastase<br />
+**[[7pqo]] – ECO (mutant) + MASP-1<br />
+**[[7pqn]] – ECO + MASP-2<br />
+}}
+== References ==
+<references/>
 [[Category:Topic Page]]