Mineralocorticoid receptor: Difference between revisions
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== Function == | == Function == | ||
'''Mineralocorticoid receptor''' (MR) in epithelial cells is activated by the mineralocorticoid hormone aldosterone promoting renal sodium retention and potassium excretion. | '''Mineralocorticoid receptor''' (MR) in epithelial cells is activated by the mineralocorticoid hormone aldosterone promoting renal sodium retention and potassium excretion. It is [[Nuclear receptors|nuclear receptor]]. In non epithelial cells MR is activated by cortisol<ref>PMID:15199296</ref>. MR is exposed to many steroids including cortisol, cortisone and progesterone, however, aldosterone and deoxycorticosterone are its physiological ligands. | ||
See also [[Mineralocorticoids]]; [[Steroid Hormones and their receptors]] and [[Intracellular receptors]] | |||
== Disease == | == Disease == | ||
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**[[2ab2]], [[3vhu]], [[2oax]] – hMR LBD (mutant) + spironolactone <br /> | **[[2ab2]], [[3vhu]], [[2oax]] – hMR LBD (mutant) + spironolactone <br /> | ||
**[[3wff]], [[3wfg]], [[4pf3]], [[3vhv]], [[5hcv]] – hMR LBD (mutant) + antagonist <br /> | **[[3wff]], [[3wfg]], [[4pf3]], [[3vhv]], [[5hcv]] – hMR LBD (mutant) + antagonist <br /> | ||
**[[6l88]] – hMR LBD (mutant) + esaxerenone<br /> | |||
**[[5mwy]], [[6gev]] – hMR LBD + NCOA1 peptide <br /> | **[[5mwy]], [[6gev]] – hMR LBD + NCOA1 peptide <br /> | ||
**[[2a3i]], [[5mwp]] – hMR LBD (mutant) + NCOA1 peptide <br /> | **[[2a3i]], [[5mwp]] – hMR LBD (mutant) + NCOA1 peptide <br /> | ||