Ricin: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Andrea Gorrell, Douglas Read, David Canner, Michal Harel, Wayne Decatur, Alexander Berchansky, Ann Taylor, Jaime Prilusky, Joel L. Sussman, Angel Herraez

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 '''Ricin''' is a potent cytotoxin that is synthesized in the endosperm cells of maturing seeds of the castor oil plant (''Ricinus communis'')<ref name="lord">PMID: 8119491</ref>. Ricin belongs to a small multi-gene family<ref name="montfort">PMID: 3558397</ref> that is composed of eight members. Ricin is classified as a type II heterodimeric Ribosome Inactivating Protein<ref name="lord" /> or RIPs.  For toxins in Proteopedia see [[Toxins]].
-See also [[Ricin: A toxic protein]].
+See also [[Ricin: A toxic protein]]; [[Ricin: Structure and function]].
 <StructureSection load='3rtj'  size='350' side='right' caption='Glycosylated ricin chain A (grey) and chain B (green) bound to dinucleotide APG (stick model) (PDB entry [[3rtj]])'>
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 ==3D structures of ricin==
 [[Ricin 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-* Ricin A chain (RTA)
-** [[1j1m]], [[1ift]], [[2aai]], [[1rtc]] – RTA<br />
-** [[3lc9]], [[3mk9]], [[2vc4]], [[1uq4]], [[1uq5]], [[1obs]], [[3srp]], [[4imv]] – RTA (mutant)
-* Ricin A chain binary complexes
-** [[3px8]] – RTA preproricin + 7-carboxy-pterin<br />
-** [[1br5]], [[1br6]], [[4esi]], [[4huo]], [[4hup]], [[4hv3]], [[4hv7]], [[4mx1]], [[4mx5]] - RTA + pterin derivative<br />
-** [[3px9]] - RTA preproricin + furanylmethyl-carbamoyl-pterin<br />
-** [[3hio]] – RTA + tetranucleotide<br />
-** [[3ej5]], [[1il5]] – RTA pyrimidine derivative<br />
-** [[2p8n]], [[1ifs]] – RTA + adenine<br />
-** [[2pjo]], [[2r2x]] – RTA + urea derivative<br />
-** [[2r3d]] – RTA + acetamide<br />
-** [[2vc3]] - RTA (mutant) + acetate<br />
-** [[1il3]], [[1il4]], [[1il9]] – RTA + guanine derivative<br />
-** [[1ifu]] – RTA + formycin<br />
-**[[4q2v]] – RTA + baicalin<br />
-** [[1obt]] - RTA (mutant) + AMP<br />
-** [[3rtj]] – RTA + RNA<br />
-** [[3px8]] – RTA + formycin monophosphate<br />
-** [[5ddz]] – RTA + ribosomal protein P2<br />
-** [[5gu4]] – RTA + peptide<br />
-** [[6urw]], [[6urx]], [[6ury]], [[7mln]], [[7mlo]], [[7mlp]], [[7mlt]] – RTA + inhibitor<br />
-** [[4kuc]], [[4lgp]], [[4lgr]], [[4lgs]], [[4lhj]], [[4lhq]], [[4z9k]], [[5boz]], [[5e1h]], [[5j56]], [[5j57]], [[5sv3]], [[5u4m]], [[5u4l]], [[6cwg]], [[6obc]], [[6obe]], [[6obg]], [[6obm]], [[6obo]], [[6oca]], [[6ocd]] – RTA + antibody<br />
-* Ricin B chain (RTB)
-** [[3nbc]], [[3nbd]] – CnRTB + lactose – ''Clitocybe nebularis''<br />
-** [[3nbe]] – CnRTB + lactose derivative<br />
-** [[3phz]] – RTB + glycoside – ''Polyporus squamosus''<br />
-** [[3vsf]] – CtRTB lectin domain – ''Clostridium thermocellum''<br />
-** [[3vsz]] – CtRTB lectin domain + galactan<br />
-** [[3vt0]] – CtRTB lectin domain + lactose<br />
-** [[3vt1]], [[3vt2]] – CtRTB lectin domain + galactose derivative<br />
-* Ricin A+B chains
-** [[2aai]] - RTA + RTB<br />
-** [[3px8]], [[3rti]] – RTA + RTB + formycin monophosphate<br />
-** [[3rtj]] - RTA + RTB + dinucleotide<br />
-**[[7kbk]], [[7kbi]], [[7kc9]], [[7kdm]], [[7kd0]], [[7kd2]], *[[7kdm]], [[7kdu]] – RTA + RTB + antibody<br />
-}}
 ==See Also==
 * [[Ribosome]]