TRAIL: Difference between revisions
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<StructureSection load='1d0g' size='340' side='right' caption='Human TRAIL trimer residues 114-281 (grey, light green, yellow) complex with death receptor-5 extracellular domain (dark blue, dark green, olive), Zn+2 (grey) and Cl-1 (green) ions, [[1d0g]]' scene=''> | <StructureSection load='1d0g' size='340' side='right' caption='Human TRAIL trimer residues 114-281 (grey, light green, yellow) complex with death receptor-5 extracellular domain (dark blue, dark green, olive), Zn+2 (grey) and Cl-1 (green) ions, [[1d0g]]' scene='' pspeed='8'> | ||
== Function == | == Function == | ||
'''TRAIL (TNF-related apoptosis-inducing ligand)''' functions as a ligand in the process of apoptosis<ref>PMID:15987601</ref>. | '''TRAIL (TNF-related apoptosis-inducing ligand)''' or '''TNF ligand superfamily 10''' functions as a ligand in the process of apoptosis<ref>PMID:15987601</ref>. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2. For details see [[Molecular Playground/TRAIL]]. '''TRAIL-R2''' is called '''DR5'''. <scene name='48/480878/Cv/3'>TRAIL trimer residues complex with death receptor-5 extracellular domain</scene> ([[1d0g]]). <scene name='48/480878/Cv/4'>Zn+2 and Cl-1 bind to 3 same Cys residues from different subunits of TRAIL trimer</scene>. | ||
See also: | |||
*[[Cytokine receptors]] | |||
*[[Immune receptors]] | |||
== Disease == | == Disease == | ||
TRAIL concentrations are reduced in rheumatoid | TRAIL concentrations are reduced in rheumatoid arthritis<ref>PMID:25962765</ref>. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of TRAIL == | == 3D Structures of TRAIL == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
TRAIL-R2 domains – extracellular 54-184; transmembrane 208-242 | |||
[[1d0g]], [[1d4v]], [[1du3]] - hTRAIL | [[1d0g]], [[1d4v]], [[1du3]], [[5cir]] - hTRAIL 114-281 + TRAIL-R2 extracellular domain - human<br /> | ||
[[1dg6]] – hTRAIL jelly-roll domain<br /> | [[4n90]] - hTRAIL 114-281 + hTRAIL-R2 extracellular domain + antibody<br /> | ||
[[1d2q]] - hTRAIL extracellular domain | [[1dg6]] – hTRAIL jelly-roll domain 91-281<br /> | ||
[[1d2q]] - hTRAIL 114-281<br /> | |||
[[4i9x]] – hTRAIL-R2 extracellular domain + UL141<br /> | |||
[[3x3f]], [[1za3]], [[4od2]], [[2h9g]], [[6t3j]] – hTRAIL-R2 extracellular domain + antibody<br /> | |||
[[6nhw]] – hTRAIL-R2 transmembrane domain - NMR<br /> | |||
[[6nhy]] – hTRAIL-R2 transmembrane domain (mutant) - NMR<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||