TRAIL: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-{{STRUCTURE_1d0g|  PDB=1d0g  | SIZE=400| SCENE= |right|CAPTION=Human TRAIL trimer residues 114-281 (grey, light green, yellow) complex with death receptor-5 extracellular domain (dark blue, dark green, olive), Zn+2 (grey) and Cl-1 (green) ions, [[1d0g]] }}
+<StructureSection load='1d0g' size='340' side='right' caption='Human TRAIL trimer residues 114-281 (grey, light green, yellow) complex with death receptor-5 extracellular domain (dark blue, dark green, olive), Zn+2 (grey) and Cl-1 (green) ions, [[1d0g]]' scene='' pspeed='8'>
+== Function ==
+'''TRAIL (TNF-related apoptosis-inducing ligand)''' or '''TNF ligand superfamily 10''' functions as a ligand in the process of apoptosis<ref>PMID:15987601</ref>. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2.  For details see [[Molecular Playground/TRAIL]]. '''TRAIL-R2''' is called '''DR5'''. <scene name='48/480878/Cv/3'>TRAIL trimer residues complex with death receptor-5 extracellular domain</scene> ([[1d0g]]). <scene name='48/480878/Cv/4'>Zn+2 and Cl-1 bind to 3 same Cys residues from different subunits of TRAIL trimer</scene>.
-'''TRAIL (TNF-related apoptosis-inducing ligand)''' functions as a ligand in the process of apoptosis.  TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2.  For details see [[Molecular Playground/TRAIL]].
+See also:
+*[[Cytokine receptors]]
-{{TOC limit|limit=2}}
+*[[Immune receptors]]
+== Disease ==
+TRAIL concentrations are reduced in rheumatoid arthritis<ref>PMID:25962765</ref>.
+</StructureSection>
 == 3D Structures of TRAIL ==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1d4v]] – hTRAIL + DR5 extracellular domain – human<br />
+TRAIL-R2 domains – extracellular 54-184; transmembrane 208-242
-[[1d0g]] - hTRAIL residues 114-281 + DR5 extracellular domain<br />
-[[1dg6]] – hTRAIL jelly-roll domain<br />
-[[1d2q]] - hTRAIL extracellular domain
+[[1d0g]], [[1d4v]], [[1du3]], [[5cir]] - hTRAIL 114-281 + TRAIL-R2 extracellular domain - human<br />
+[[4n90]] - hTRAIL 114-281 + hTRAIL-R2 extracellular domain + antibody<br />
+[[1dg6]] – hTRAIL jelly-roll domain 91-281<br />
+[[1d2q]] - hTRAIL 114-281<br />
+[[4i9x]] – hTRAIL-R2 extracellular domain + UL141<br />
+[[3x3f]], [[1za3]], [[4od2]], [[2h9g]], [[6t3j]] – hTRAIL-R2 extracellular domain + antibody<br />
+[[6nhw]] – hTRAIL-R2 transmembrane domain - NMR<br />
+[[6nhy]] – hTRAIL-R2 transmembrane domain (mutant) - NMR<br />
+== References ==
+<references/>
 [[Category:Topic Page]]