Troponin: Difference between revisions

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{{STRUCTURE_1yv0|  PDB=1yv0 | SIZE=400| SCENE=Troponin/Cv/1 |right|CAPTION=Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]] }}
<StructureSection load='1yv0' size='350' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''>


__TOC__
== Function ==
[[Troponin]] (Tn) is a regulatory protein in muscle contraction.  It contains 3 subunits:<br />
[[Troponin]] (Tn) is a regulatory protein in muscle contraction.  It contains 3 subunits:<br />
* '''TnC''' causes conformational change in TnI when it binds to calcium ions.  For more details on TnC see<br />
* '''TnC''' causes conformational change in TnI when it binds to calcium ions<ref>PMID:26232335</ref>.  For more details on TnC see<br />
[[ Role of Troponin C in decreased muscle sensitivity to calcium]]<br />
[[ Role of Troponin C in decreased muscle sensitivity to calcium]]<br />
[[Human Cardiac Troponin C]]<br />
[[Human Cardiac Troponin C]]<br />
[[Human Cardiac Troponin C in complex with the Green Tea Polyphenol]]<br />.
[[Human Cardiac Troponin C in complex with the Green Tea Polyphenol]]<br />
* '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br />
* '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br />
* '''TnI''' binds to actin which is found in thin muscle filaments.<br />
* '''TnI''' binds to actin which is found in thin muscle filaments. See [[Human Cardiac Troponin I]]<br />
 
== Disease ==
Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy.


== 3D Structures of Troponin ==
== 3D Structures of Troponin ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[Troponin 3D structures]]
{{#tree:id=OrganizedByTopic|openlevels=0|
 
* Troponin C+Troponin I+Troponin T
 
**[[2w49]], [[2w4u]] – cTnC+cTnI+cTnT+tropomyosin+actin – chicken<br />
**[[1ytz]] - cTnC+cTnI+cTnT+Ca<br />
**[[1yv0]] - cTnC+cTnI+cTnT<br />
**[[1j1d]], [[1j1e]] – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca - human
 
* Troponin C+Troponin I
 
**[[2krd]], [[2mkp]] – hTnC+hTnI  – NMR<br />
**[[1ozs]] - hTnC C-terminal+hTnI N-terminal – NMR<br />
**[[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br />
**[[1lxf]], [[1mxl]] - hTnC N-terminal+hTnI fragment<br />
**[[2kgb]] – hTnC (mutant) regulatory domain+TnI<br />
**[[2mzp]] - hTnC regulatory domain+TnI switch region (mutant) <br />
**[[1sbj]] – cTnC C-terminal+cTnI N-terminal+Mg - NMR<br />
**[[1scv]], [[1fi5]], [[1blq]] - cTnC C-terminal+cTnI N-terminal – NMR<br />
**[[1npq]] - cTnC (mutant) N-terminal+cTnI  fragment+rhodamine<br />
**[[1jc2]] - cTnC C-terminal+cTnI N-terminal<br />
**[[1a2x]] - rTnC +rTnI fragment – rabbit<br />
**[[3tz1]] - TnC C terminal +TnI fragment – akazara scallop<br />
 
* Troponin C
 
**[[2kdh]] – hTnC+green tea polyphenol – NMR<br />
**[[2kfx]] – hTnC (mutant) N-terminal+Ca+naphthalene derivative<br />
**[[2jt0]], [[2jtz]], [[2jt8]], [[2jt3]] – hTnC (mutant) – NMR<br />
**[[2jxl]] - hTnC (mutant) N-terminal – NMR<br />
**[[3rv5]], [[3sd6]], [[3swb]] - hTnC N-terminal<br />
**[[4gjg]] - hTnC N-terminal (mutant)<br />
**[[4gjf]] - hTnC N-terminal (mutant) + Cd<br />
**[[4gje]] - hTnC N-terminal + Cd<br />
**[[1wrk]], [[1wrl]] - hTnC (mutant) N-terminal+trifluoperazine<br />
**[[1spy]] - hTnC  N-terminal – NMR<br />
**[[2mle]] - hTnC  C-terminal – NMR<br />
**[[2mlf]] - hTnC  C-terminal (mutant) – NMR<br />
**[[1ih0]] - hTnC C-terminal+EMD 57033 – NMR<br />
**[[1ap4]] - hTnC N-terminal+Ca – NMR<br />
**[[2l98]] – hTnC EF-hand domains 3,4 + resveratrol<br />
**[[1la0]], [[4tnc]] – cTnC+Ca<br />
**[[1dtl]] – cTnC (mutant)+Ca +bepridil<br />
**[[1skt]], [[1zac]], [[2ctn]] - cTnC N-terminal – NMR<br />
**[[1aj4]] - cTnC (mutant) +Ca – NMR<br />
**[[3ctn]] - cTnC C-terminal – NMR<br />
**[[1avs]] - cTnC N-terminal+Ca<br />
**[[1smg]], [[1tnq]] - cTnC N-terminal+Ca - NMR<br />
**[[1ncy]] – cTnC+Mn<br />
**[[1ncx]], [[1ncz]], [[1top]] – cTnC<br />
**[[1pon]], [[1cta]], [[1ctd]] – cTnC fragment – NMR<br />
**[[1tnp]] - cTnC N-terminal – NMR<br />
**[[1tnw]], [[1tnx]] - cTnC +Ca - NMR<br />
**[[1trf]] - tTnC N-terminal+Ca - turkey – NMR<br />
**[[5tnc]] - tTnC<br />
**[[2k2a]] - TnC  C-terminal – ''Lethocerus indicus'' – NMR<br />
**[[2jnf]] – TnC – fly – NMR<br />
**[[1r2u]], [[1r6p]] - TnC  N-terminal – trout – NMR<br />
**[[1tcf]] – rTnC+Ca<br />
**[[1tn4]], [[2tn4]] – rTnC (mutant)+Ca
 
* Troponin I
 
**[[2jpw]] – TnI biphosphorylated – mouse – NMR<br />
**[[1vdi]] – cTnI – NMR<br />
**[[1vdj]] – cTnI+Ca - NMR


* Troponin T
</StructureSection>


**[[2z5h]] – yTnT fragment+tropomyosin – yeast
== References ==
}}
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 12:51, 11 January 2023


Function

Troponin (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:

  • TnC causes conformational change in TnI when it binds to calcium ions[1]. For more details on TnC see

Role of Troponin C in decreased muscle sensitivity to calcium

Human Cardiac Troponin C
Human Cardiac Troponin C in complex with the Green Tea Polyphenol

Disease

Mutations in TnI[2] and TnT [3]are associated with hypertrophic cardiomyopathy.

3D Structures of Troponin

Troponin 3D structures


Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) 1yv0

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Li MX, Hwang PM. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene. 2015 Oct 25;571(2):153-66. doi: 10.1016/j.gene.2015.07.074. Epub 2015 Jul, 29. PMID:26232335 doi:http://dx.doi.org/10.1016/j.gene.2015.07.074
  2. ↑ Kimura A, Harada H, Park JE, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagi T, Hwang TH, Choo JA, Chung KS, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet. 1997 Aug;16(4):379-82. PMID:9241277 doi:10.1038/ng0897-379
  3. ↑ Palm T, Graboski S, Hitchcock-DeGregori SE, Greenfield NJ. Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region. Biophys J. 2001 Nov;81(5):2827-37. PMID:11606294 doi:http://dx.doi.org/10.1016/S0006-3495(01)75924-3

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Alexander Berchansky, Michal Harel, Joel L. Sussman
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