Troponin: Difference between revisions

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New page: left|200px|thumb|Crystal Structure of Troponin [[1yv0]] {{STRUCTURE_1yv0| PDB=1yv0 | SIZE=300| SCENE= |right|CAPTION=Troponin 1yv0 }} Troponin (Tn) is a regul...
 
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[[Image:1yv0.png|left|200px|thumb|Crystal Structure of Troponin [[1yv0]]]]
<StructureSection load='1yv0' size='350' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''>
{{STRUCTURE_1yv0|  PDB=1yv0 | SIZE=300| SCENE= |right|CAPTION=Troponin [[1yv0]] }}


[[Troponin]] (Tn) is a regulatory protein in muscle contraction.  It contains 3 subunits: TnC causes conformational change in TnI when it binds to calcium ions.  TnT binds to [[Tropomyosin|tropomyosin]] and TnI binds to actin which is found in thin muscle filaments. The images at the left and at the right correspond to one representative Tn, ''i.e.'' the crystal structure of Troponin C + Troponin I + Troponin T of chicken ([[1yv0]]).
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== Function ==
[[Troponin]] (Tn) is a regulatory protein in muscle contraction.  It contains 3 subunits:<br />
* '''TnC''' causes conformational change in TnI when it binds to calcium ions<ref>PMID:26232335</ref>.  For more details on TnC see<br />
[[ Role of Troponin C in decreased muscle sensitivity to calcium]]<br />
[[Human Cardiac Troponin C]]<br />
[[Human Cardiac Troponin C in complex with the Green Tea Polyphenol]]<br />
* '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br />
* '''TnI''' binds to actin which is found in thin muscle filaments.  See [[Human Cardiac Troponin I]]<br />
 
== Disease ==
Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy.


== 3D Structures of Troponin ==
== 3D Structures of Troponin ==


[[Troponin 3D structures]]


</StructureSection>


Troponin C+Troponin I+Troponin T
== References ==
 
<references/>
2w49 – cTnC+cTnI+cTnT+tropomyosin+actin – chicken
[[Category:Topic Page]]
1ytz - cTnC+cTnI+cTnT+Ca++
1yv0 - cTnC+cTnI+cTnT
1j1d, 1j1e – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca++ - human
 
Troponin C+Troponin I
 
2krd – hTnC+hTnI  – NMR
1ozs - hTnC C-terminal+hTnI N-terminal – NMR
1lxf, 1mxl - hTnC N-terminal+hTnI fragment
2kgb – hTnC (mutant) regulatory domain+TnI
1sbj – cTnC C-terminal+cTnI N-terminal+Mg++ - NMR
1scv, 1fi5, 1blq - cTnC C-terminal+cTnI N-terminal – NMR
1npq - cTnC (mutant) N-terminal+cTnI  fragment+rhodamine
1jc2 - cTnC C-terminal+cTnI N-terminal
1a2x - rTnC +rTnI fragment – rabbit
 
Troponin C
 
2kdh – hTnC+green tea polyphenol – NMR
2kfx – hTnC (mutant) N-terminal+Ca+naphthalene derivative
2jt0, 2jtz, 2jt8, 2jt3 – hTnC (mutant) – NMR
2jxl - hTnC (mutant) N-terminal – NMR
1wrk, 1wrl - hTnC (mutant) N-terminal+trifluoperazine
1spy - hTnC  N-terminal– NMR
1ih0 - hTnC C-terminal+EMD 57033 – NMR
1ap4 - hTnC N-terminal+Ca++ – NMR
1la0, 4tnc – cTnC+Ca++
1dtl – cTnC (mutant)+Ca++ +bepridil
1skt, 1zac, 2ctn- cTnC N-terminal – NMR
1aj4 - cTnC (mutant) +Ca++ – NMR
1ctn - cTnC C-terminal – NMR
1avs - cTnC N-terminal+Ca++
1smg, 1tnq - cTnC N-terminal+Ca++ - NMR
1ncy – cTnC+Mn++
1ncx, 1ncz, 1top – cTnC
1pon, 1cta, 1ctd – cTnC fragment – NMR
1tnp - cTnC N-terminal – NMR
1tnw, 1tnx - cTnC +Ca++ - NMR
1trf - tTnC N-terminal+Ca++ - turkey – NMR
5tnc - tTnC
2k2a - TnC  C-terminal – Lethocerus indicus – NMR
2jnf – TnC – fly – NMR
1r2u, 1r6p - TnC  N-terminal – trout – NMR
1tcf – rTnC+Ca++
1tn4, 2tn4 – rTnC (mutant)+Ca++
 
Troponin I
2jpw – TnI biphosphorylated – mouse – NMR
1vdi – cTnI – NMR
1vdj – cTnI+Ca++ - NMR
 
Troponin T
 
2z5h – yTnT fragment+tropomyosin – yeast

Latest revision as of 12:51, 11 January 2023


Function

Troponin (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:

  • TnC causes conformational change in TnI when it binds to calcium ions[1]. For more details on TnC see

Role of Troponin C in decreased muscle sensitivity to calcium

Human Cardiac Troponin C
Human Cardiac Troponin C in complex with the Green Tea Polyphenol

Disease

Mutations in TnI[2] and TnT [3]are associated with hypertrophic cardiomyopathy.

3D Structures of Troponin

Troponin 3D structures


Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) 1yv0

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Li MX, Hwang PM. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene. 2015 Oct 25;571(2):153-66. doi: 10.1016/j.gene.2015.07.074. Epub 2015 Jul, 29. PMID:26232335 doi:http://dx.doi.org/10.1016/j.gene.2015.07.074
  2. ↑ Kimura A, Harada H, Park JE, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagi T, Hwang TH, Choo JA, Chung KS, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet. 1997 Aug;16(4):379-82. PMID:9241277 doi:10.1038/ng0897-379
  3. ↑ Palm T, Graboski S, Hitchcock-DeGregori SE, Greenfield NJ. Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region. Biophys J. 2001 Nov;81(5):2827-37. PMID:11606294 doi:http://dx.doi.org/10.1016/S0006-3495(01)75924-3

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