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| == Function == | | == Function == |
| '''Malate synthase''' (MS) catalyzes the reversible conversion of acetyl-CoA, glyoxylate and water to [[R/S nomenclature|(S)]]-malate and CoA. MS participates in pyruvate, glyoxylate and dicarboxylate metabolism. There are 2 isozymes of MS. '''MS G''' is formed during growth on glycolate<ref>PMID:12930982</ref> and '''MS A''' which metabolizes glyoxylate formed in the dissimilation of acetate. | | '''Malate synthase''' (MS) catalyzes the reversible conversion of acetyl-CoA, glyoxylate and water to [[R/S nomenclature|(S)]]-malate and CoA. MS participates in pyruvate, glyoxylate and dicarboxylate metabolism. There are 2 isozymes of MS. '''MS G''' is formed during growth on glycolate<ref>PMID:12930982</ref> and '''MS A''' which metabolizes glyoxylate formed in the dissimilation of acetate. |
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| | See also: [[Glyoxylate cycle]] |
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| == Structural highlights == | | == Structural highlights == |
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| </StructureSection> | | </StructureSection> |
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| ==3d structures of malate synthase==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *'''Malate synthase'''
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| **[[1y8b]], [[2jqx]] – EcMS G (mutant) – ''Escherichia coli'' - NMR<br />
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| **[[3cuz]], [[3cv1]] – EcMS A<br />
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| **[[4ex4]] – MS G + Mg – ''Mycobacterium leprae''<br />
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| **[[5h8p]] – MtMS G – ''Mycobacterium tuberculosis''<br />
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| **[[5h8m]] – MtMS G (mutant) + Mg <br />
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| **[[3cux]] – MS + Mg – ''Bacillus anthracis''<br />
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| **[[5oas]] – PaMS G + Mg – ''Pseudomonas aeruginosa''<br />
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| *Malate synthase binary complex
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| **[[1d8c]] – EcMS G (mutant) + glyoxylate + Mg <br />
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| **[[3cv2]] – EcMS A + oxalate + Mg <br />
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| **[[1n8i]] – MtMS G + glyoxylate + Mg <br />
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| **[[5h8u]] – MtMS G + malate + Mg <br />
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| **[[6axe]] – MtMS G + acetyl CoA + Mg <br />
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| **[[5c7v]], [[5cah]], [[5cjm]], [[5e9x]] – MtMS G (mutant) + pyrrole derivative + Mg <br />
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| **[[5cew]] – MtMS G (mutant) + pyridine derivative + Mg <br />
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| **[[5cjn]] – MtMS G (mutant) + quinoxaline derivative + Mg <br />
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| **[[5dx7]] – MtMS G (mutant) + isoxazole derivative + Mg <br />
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| **[[5c9r]], [[5c9u]], [[5c9w]], [[5cbj]], [[5ccz]] – MtMS G (mutant) + phenyl derivative + Mg <br />
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| **[[5c9x]], [[5cbi]] – MtMS G (mutant) + benzoate derivative + Mg <br />
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| **[[5cak]], [[5cbb]], [[5cc3]], [[5cc5]], [[5cc6]], [[5cc7]], [[5drc]], [[5dri]], [[5ecv]] – MtMS G (mutant) + indole derivative + Mg <br />
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| **[[5t8g]] – MtMS G (mutant) + thiophene derivative + Mg <br />
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| **[[6dnp]], [[6dlj]], [[6dko]], [[6c8p]], [[6c7b]], [[6c6o]], [[6c2x]], [[6ba7]], [[6axb]], [[6au9]] – MtMS G + diketoacid inhibitor + Mg <br />
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| **[[6dl9]], [[6bu1]], [[6asu]], [[6as6]], [[6apz]] – MtMS G (mutant) + phenyldiketoacid inhibitor + Mg <br />
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| **[[3s9i]], [[3s9z]], [[3sad]], [[3saz]], [[3sb0]] – MtMS G (mutant) + inhibitor + Mg <br />
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| **[[3oyx]], [[3pug]] – HvMS G + glyoxylate + Mg – ''Haloferax volcanii''<br />
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| **[[5tao]] – HvMS G + glyoxylate + Pb<br />
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| **[[5vfb]] – PaMS + glycolate + Ni<br />
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| *Malate synthase ternary complex
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| **[[1p7t]] – EcMS G (mutant) + pyruvate + Mg + acetyl-CoA<br />
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| **[[3oyz]] – HvMS + pyruvate + Mg + acetyl-CoA<br />
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| **[[1n8w]] – MtMS G + glyoxylate + Mg + CoA<br />
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| **[[2gq3]] – MtMS G + malate + Mg + CoA<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |