UMP/CMP kinase: Difference between revisions
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<StructureSection load='1tev' size='350' side='right' caption='Structure of human UMP/CMP kinase complex with sulfate (PDB entry [[1tev]])' scene='69/698098/Cv/1'> | |||
== Function == | |||
'''UMP/CMP kinase''' (UCK) or '''uridylmonophosphate/cytidylmonophosphate kinase''' phosphorylates UMP, CMP and deoxy-CMP<ref>PMID:12694191</ref>. | |||
== Relevance == | |||
Several cytidine and deoxycytidine analogs are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to exert their fully therapeutic effect. This phosphorylation is done by UCK<ref>PMID:11912132</ref>. | |||
</StructureSection> | |||
== 3D Structures of UMP/CMP kinase == | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[1tev]], [[7e9v]] – UCK – human <br /> | |||
[[2ukd]], [[3ukd]], [[1qf9]], [[5ukd]] – smUCK + ADP + CMP – slime mold <br /> | |||
[[4ukd]] – smUCK + ADP + UDP <br /> | |||
[[1uke]] – smUCK + inhibitor<br /> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | |||
Latest revision as of 11:11, 20 June 2022
FunctionUMP/CMP kinase (UCK) or uridylmonophosphate/cytidylmonophosphate kinase phosphorylates UMP, CMP and deoxy-CMP[1]. RelevanceSeveral cytidine and deoxycytidine analogs are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to exert their fully therapeutic effect. This phosphorylation is done by UCK[2].
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3D Structures of UMP/CMP kinase3D Structures of UMP/CMP kinase
Updated on 20-June-2022
1tev, 7e9v – UCK – human
2ukd, 3ukd, 1qf9, 5ukd – smUCK + ADP + CMP – slime mold
4ukd – smUCK + ADP + UDP
1uke – smUCK + inhibitor
ReferencesReferences
- ↑ Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D. Reaction of human UMP-CMP kinase with natural and analog substrates. Eur J Biochem. 2003 Apr;270(8):1784-90. PMID:12694191
- ↑ Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 2002 Mar 15;62(6):1624-31. PMID:11912132