SARS-CoV-2 protein ORF8: Difference between revisions
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<StructureSection load=' | <StructureSection load='7JTL' size='350' side='right' caption='Crystal structure of the SARS-CoV-2 Protein ORF8 (PDB: [7JTL)' scene='84/842074/7jtl_orf8/1'> | ||
== Function == | == Function == | ||
'''Open Reading Frame 8 (ORF8)''' | '''Open Reading Frame 8 (ORF8)''' may play a role in host-virus interaction. Similar to some Bat coronavirus ns8 genes, but is entirely different from SARS ns8a or ns8b<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>. | ||
<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref> | |||
== Disease == | == Disease == | ||
ORF8 contributes to the virulence of SARS-CoV-2 in COVID-19<ref>PMID: 33361333</ref>. | ORF8 contributes to the virulence of SARS-CoV-2 in COVID-19<ref>PMID: 33361333</ref>. | ||
== Relevance == | == Relevance == | ||
| Line 12: | Line 11: | ||
== See also == | == See also == | ||
[[Coronavirus_Disease 2019 (COVID-19)]] | [[Coronavirus_Disease 2019 (COVID-19)]]<br> | ||
[[SARS-CoV-2_virus_proteins]]<br> | |||
[[COVID-19 AlphaFold2 Models]] | |||
__NOTOC__ | __NOTOC__ | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Latest revision as of 17:56, 14 February 2022
FunctionOpen Reading Frame 8 (ORF8) may play a role in host-virus interaction. Similar to some Bat coronavirus ns8 genes, but is entirely different from SARS ns8a or ns8b[1][2]. DiseaseORF8 contributes to the virulence of SARS-CoV-2 in COVID-19[3]. RelevanceStructural highlightsSee alsoCoronavirus_Disease 2019 (COVID-19) SARS-CoV-2_virus_proteins
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ReferencesReferences
- ↑ Modeling of the SARS-COV-2 Genome
- ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129
- ↑ Flower TG, Buffalo CZ, Hooy RM, Allaire M, Ren X, Hurley JH. Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2). pii: 2021785118. doi:, 10.1073/pnas.2021785118. PMID:33361333 doi:http://dx.doi.org/10.1073/pnas.2021785118