SARS-CoV-2 protein ORF8

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Function

Open Reading Frame 8 (ORF8) may play a role in host-virus interaction. Similar to some Bat coronavirus ns8 genes, but is entirely different from SARS ns8a or ns8b[1][2].

Disease

ORF8 contributes to the virulence of SARS-CoV-2 in COVID-19[3].

Relevance

Structural highlights

See also

Coronavirus_Disease 2019 (COVID-19)

SARS-CoV-2_virus_proteins
COVID-19 AlphaFold2 Models


Crystal structure of the SARS-CoV-2 Protein ORF8 (PDB: [7JTL)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Modeling of the SARS-COV-2 Genome
  2. ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129
  3. ↑ Flower TG, Buffalo CZ, Hooy RM, Allaire M, Ren X, Hurley JH. Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2). pii: 2021785118. doi:, 10.1073/pnas.2021785118. PMID:33361333 doi:http://dx.doi.org/10.1073/pnas.2021785118

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