SARS-CoV-2 protein ORF8: Difference between revisions

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<SX viewer='molstar' load='' size='340' side='right' caption='' scene=''>
<StructureSection load='7JTL' size='350' side='right' caption='Crystal structure of the SARS-CoV-2 Protein ORF8 (PDB: [7JTL)' scene='84/842074/7jtl_orf8/1'>
{{Theoretical_model}}
<span class="text-red">This page needs updating. There are now two [[empirical models]] for ORF8: [[7jtl]] and [[7jx6]].</span>
== Function ==
== Function ==
'''Open Reading Frame 8 (ORF8)'''
'''Open Reading Frame 8 (ORF8)''' may play a role in host-virus interaction. Similar to some Bat coronavirus ns8 genes, but is entirely different from SARS ns8a or ns8b<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>.
<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>


== Disease ==
== Disease ==
ORF8 contributes to the virulence of SARS-CoV-2 in COVID-19<ref>PMID: 33361333</ref>.


== Relevance ==
== Relevance ==
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== See also ==
== See also ==
[[Coronavirus_Disease 2019 (COVID-19)]]
[[Coronavirus_Disease 2019 (COVID-19)]]<br>
[[SARS-CoV-2_virus_proteins]]<br>
[[COVID-19 AlphaFold2 Models]]
__NOTOC__
__NOTOC__
</SX>
</StructureSection>
 
== References ==
== References ==
<references/>
<references/>

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Jaime Prilusky, Eric Martz, Joel L. Sussman