Mandelate racemase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Karsten Theis

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 <StructureSection load='1mdr' size='350' side='right' caption='Structure of mandelate racemase complex with reaction intermediate phenyl-lactate and Mg+2 ion (green)  (PDB entry [[1mdr]])' scene='51/516478/Cv/1'>
 == Function ==
-'''Mandelate rasemase''' (MAR) catalyzes the interconversion of enantiomers of mandelate (S to R).  MAR is Mg-dependent.  MAR can racemize other alpha-hydroxy carbonyl compounds.  MAR is involved in aromatic acids catabolism<ref>PMID:1892833</ref>.
+'''Mandelate racemase''' (MAR) catalyzes the interconversion of enantiomers of mandelate [[R/S nomenclature|(S to R)]].  MAR is Mg-dependent.  MAR can racemize other alpha-hydroxy carbonyl compounds.  MAR is involved in aromatic acids catabolism<ref>PMID:1892833</ref>.
 == Structural highlights ==
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 **[[1mns]], [[1mdr]] – PpMAR + α-phenyl lactate <br />
-**[[3ops]] – GeMAR + lactate<br />
 **[[1mra]], [[1dtn]] – PpMAR (mutant) + atrolactate<br />
 **[[1mdl]] - PpMAR (mutant) + mandelate<br />
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 **[[4fp1]] – PpMAR + inhibitor<br />
 **[[4x2p]] – PpMAR + 3-hydroxypyruvate<br />
-**[[3tte]] - BrMAR + mandelate<br />
+**[[6vim]], [[7mqx]] – PpMAR + boronic acid derivative<br />
 **[[3uxk]], [[3uxl]] – PpMAR + intermediate analog<br />
 **[[3sbf]] – VbMAR (mutant) + arabinonate <br />
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 **[[4gfi]] – AtMAR + dipeptide epimerase<br />
 **[[4h19]] – AtMAR + ribonohydroxamate<br />
+**[[3ops]] – GeMAR + lactate<br />
+**[[3tte]] - BrMAR + mandelate<br />
 }}
 == References ==