Mandelate racemase: Difference between revisions
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<StructureSection load='1mdr' size=' | <StructureSection load='1mdr' size='350' side='right' caption='Structure of mandelate racemase complex with reaction intermediate phenyl-lactate and Mg+2 ion (green) (PDB entry [[1mdr]])' scene='51/516478/Cv/1'> | ||
== Function == | == Function == | ||
'''Mandelate | '''Mandelate racemase''' (MAR) catalyzes the interconversion of enantiomers of mandelate [[R/S nomenclature|(S to R)]]. MAR is Mg-dependent. MAR can racemize other alpha-hydroxy carbonyl compounds. MAR is involved in aromatic acids catabolism<ref>PMID:1892833</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
The active site of MAR binds the reaction intermediate<ref>PMID:8292591</ref>. | The biological assembly of mandelate racemase from ''Pseudomonas putida'' is <scene name='51/516478/Cv/7'>homooctamer</scene>. The <scene name='51/516478/Cv/8'>active site of MAR binds the reaction intermediate</scene><ref>PMID:8292591</ref>. Water molecule are shown as red sphere. | ||
</StructureSection> | </StructureSection> | ||
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**[[1mns]], [[1mdr]] – PpMAR + α-phenyl lactate <br /> | **[[1mns]], [[1mdr]] – PpMAR + α-phenyl lactate <br /> | ||
**[[1mra]], [[1dtn]] – PpMAR (mutant) + atrolactate<br /> | **[[1mra]], [[1dtn]] – PpMAR (mutant) + atrolactate<br /> | ||
**[[1mdl]] - PpMAR (mutant) + mandelate<br /> | **[[1mdl]] - PpMAR (mutant) + mandelate<br /> | ||
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**[[4m6u]] - PpMAR + tartronic acid<br /> | **[[4m6u]] - PpMAR + tartronic acid<br /> | ||
**[[4fp1]] – PpMAR + inhibitor<br /> | **[[4fp1]] – PpMAR + inhibitor<br /> | ||
**[[ | **[[4x2p]] – PpMAR + 3-hydroxypyruvate<br /> | ||
**[[6vim]], [[7mqx]] – PpMAR + boronic acid derivative<br /> | |||
**[[3uxk]], [[3uxl]] – PpMAR + intermediate analog<br /> | **[[3uxk]], [[3uxl]] – PpMAR + intermediate analog<br /> | ||
**[[3sbf]] – VbMAR (mutant) + arabinonate <br /> | **[[3sbf]] – VbMAR (mutant) + arabinonate <br /> | ||
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**[[4gfi]] – AtMAR + dipeptide epimerase<br /> | **[[4gfi]] – AtMAR + dipeptide epimerase<br /> | ||
**[[4h19]] – AtMAR + ribonohydroxamate<br /> | **[[4h19]] – AtMAR + ribonohydroxamate<br /> | ||
**[[3ops]] – GeMAR + lactate<br /> | |||
**[[3tte]] - BrMAR + mandelate<br /> | |||
}} | }} | ||
== References == | == References == | ||