3d6u: Difference between revisions

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-[[Image:3d6u.png|left|200px]]
-{{STRUCTURE_3d6u|  PDB=3d6u  |  SCENE=  }}
+==Crystal structure of 4-(trifluoromethyldiazirinyl)phenylalanyl-tRNA synthetase==
+<StructureSection load='3d6u' size='340' side='right'caption='[[3d6u]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-===Crystal structure of 4-(trifluoromethyldiazirinyl)phenylalanyl-tRNA synthetase===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3d6u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43067 Atcc 43067]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2q1g 2q1g]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D6U FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=T11:4-[3-(TRIFLUOROMETHYL)DIAZIRIDIN-3-YL]-L-PHENYLALANINE'>T11</scene></td></tr>
-==About this Structure==
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j1u|1j1u]], [[3d6v|3d6v]]</div></td></tr>
-[[3d6u]] is a 1 chain structure of [[Aminoacyl tRNA Synthetase]] with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2q1g 2q1g]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6U OCA].
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tyrS, MJ0389 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 ATCC 43067])</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d6u OCA], [https://pdbe.org/3d6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d6u RCSB], [https://www.ebi.ac.uk/pdbsum/3d6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d6u ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[https://www.uniprot.org/uniprot/SYY_METJA SYY_METJA]] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).<ref>PMID:10585437</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d6/3d6u_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d6u ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
+*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:018000916</ref><references group="xtra"/>
+__TOC__
-[[Category: Methanocaldococcus jannaschii]]
+</StructureSection>
+[[Category: Atcc 43067]]
+[[Category: Large Structures]]
 [[Category: Tyrosine--tRNA ligase]]
-[[Category: Liu, W.]]
+[[Category: Liu, W]]
-[[Category: Mack, A V.]]
+[[Category: Mack, A V]]
-[[Category: Schultz, P G.]]
+[[Category: Schultz, P G]]
-[[Category: Tippmann, E.]]
+[[Category: Tippmann, E]]
 [[Category: Aminoacyl-trna synthetase]]
 [[Category: Atp-binding]]
+[[Category: Cytoplasm]]
 [[Category: Ligase]]
 [[Category: Nucleotide-binding]]
 [[Category: Photocrosslinking unnatural amino acid]]
 [[Category: Protein biosynthesis]]