F-actin capping protein: Difference between revisions

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{{STRUCTURE_3lk4|  PDB=3lk4  | SIZE=400| SCENE= |right|CAPTION=F-actin capping protein α and β subunits complex with CD2-associated protein, [[3lk4]] }}
<StructureSection load='3aa7' size='350' side='right' scene='50/508421/Cv/1' caption='F-actin capping protein α (cyan) and β subunits (magenta) complex with ethanosulfonic acid and Ba+2 ion (PDB code [[3aa7]]) '>


    
    
'''F-actin capping protein''' (CAPZ) regulates growth of actin filaments by capping the barbed end of the growing filament thus blocking the exchange of subunits at this end. CAPZ is a heterodimer with α and β subunits. For more details see [[Group:MUZIC:CapZ]].
'''F-actin capping protein''' (CapZ) regulates growth of actin filaments by capping the barbed end of the growing filament thus blocking the exchange of subunits at this end. <scene name='50/508421/Cv/4'>CapZ is a heterodimer with α and β subunits</scene>. <scene name='50/508421/Cv/5'>Ba+2 ion coordination site</scene> in CapZ (PDB code [[3aa7]])<ref>PMID:20625546</ref>, water molecules are shown as red sphesres. For more details see [[Group:MUZIC:CapZ]].
</StructureSection>


==3D structures of F-actin capping protein==
==3D structures of F-actin capping protein==


[[1izn]] – cCAPZ α1+β – chicken<br />
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[3aa7]] - cCAPZ α1+β (mutant)<br />
 
[[2kbm]] - CAPZ α2 + S-100 calcium-binding protein]] - rat<br />
[[6f3a]], [[6f38]], [[6f1u]], [[6f1t]], [[5nw4]], [[5afu]] - pCAPZ β in dynactin dynein complex – pig – Cryo EM<br />
[[3lk2]], [[3lk3]] - cCAPZ α1+β + leucine-rich repeat-containing protein 16A<br />
[[6znl]] - pCAPZ α1+β2 in dynactin complex – Cryo EM<br />
[[3aa0]] - cCAPZ α1+β (mutant) + leucine-rich repeat-containing protein 16A peptide<br />
[[5adx]] - pCAPZ α1+β2 + dynactin + actin – Cryo EM<br />
[[3aae]] - cCAPZ α1+β + leucine-rich repeat-containing protein 16A peptide<br />
[[1izn]] – cCapZ α1+β – chicken<br />
[[3aa1]] - cCAPZ α1+β (mutant) + CKIP-1 peptide<br />
[[3aa7]] - cCapZ α1+β (mutant)<br />
[[2kz7]] - cCAPZ α1+β + leucine-rich repeat-containing protein 16A]] - NMR<BR />
[[2kbm]] - CapZ α2 + S-100 calcium-binding protein - rat<br />
[[3lk4]] - cCAPZ α1+β + CD2-associated protein<br />
[[3lk2]], [[3lk3]] - cCapZ α1+β + leucine-rich repeat-containing protein 16A<br />
[[3aa6]] - cCAPZ α1+β (mutant) + CD2-associated protein peptide<br />
[[3aa0]] - cCapZ α1+β (mutant) + leucine-rich repeat-containing protein 16A peptide<br />
[[2kxp]] - cCAPZ α1+β + myotrophin – NMR<BR />
[[3aae]] - cCapZ α1+β + leucine-rich repeat-containing protein 16A peptide<br />
[[3aaa]] - cCAPZ α1+β + myotrophin
[[3aa1]] - cCapZ α1+β (mutant) + CKIP-1 peptide<br />
[[2kz7]] - cCapZ α1+β + leucine-rich repeat-containing protein 16A]] - NMR<BR />
[[3lk4]] - cCapZ α1+β + CD2-associated protein<br />
[[3aa6]] - cCapZ α1+β (mutant) + CD2-associated protein peptide<br />
[[2kxp]] - cCapZ α1+β + myotrophin – NMR<BR />
[[3aaa]], [[7dsa]] - cCapZ α1+β + myotrophin<br />
[[7ds2]], [[7ds4]], [[7ds6]], [[7ds8]] - cCAPZ α1+β + twinfilin-1<br />
[[7ds3]] - cCAPZ α1+β + twinfilin-2<br />
[[7ccc]] - cCAPZ α1+β + twinfilin-1 + ADP<br />
[[7dsb]] - cCAPZ α1+β + twinfilin-1 + myotrophin<br />
[[4akr]] - CAPZ α1+β – slime mold<br />
 
== References ==
<references/>
 
[[Category:Topic Page]]

Latest revision as of 13:23, 21 July 2021


F-actin capping protein (CapZ) regulates growth of actin filaments by capping the barbed end of the growing filament thus blocking the exchange of subunits at this end. . in CapZ (PDB code 3aa7)[1], water molecules are shown as red sphesres. For more details see Group:MUZIC:CapZ.

F-actin capping protein α (cyan) and β subunits (magenta) complex with ethanosulfonic acid and Ba+2 ion (PDB code 3aa7)

Drag the structure with the mouse to rotate

3D structures of F-actin capping protein3D structures of F-actin capping protein

Updated on 21-July-2021

6f3a, 6f38, 6f1u, 6f1t, 5nw4, 5afu - pCAPZ β in dynactin dynein complex – pig – Cryo EM
6znl - pCAPZ α1+β2 in dynactin complex – Cryo EM
5adx - pCAPZ α1+β2 + dynactin + actin – Cryo EM
1izn – cCapZ α1+β – chicken
3aa7 - cCapZ α1+β (mutant)
2kbm - CapZ α2 + S-100 calcium-binding protein - rat
3lk2, 3lk3 - cCapZ α1+β + leucine-rich repeat-containing protein 16A
3aa0 - cCapZ α1+β (mutant) + leucine-rich repeat-containing protein 16A peptide
3aae - cCapZ α1+β + leucine-rich repeat-containing protein 16A peptide
3aa1 - cCapZ α1+β (mutant) + CKIP-1 peptide
2kz7 - cCapZ α1+β + leucine-rich repeat-containing protein 16A]] - NMR
3lk4 - cCapZ α1+β + CD2-associated protein
3aa6 - cCapZ α1+β (mutant) + CD2-associated protein peptide
2kxp - cCapZ α1+β + myotrophin – NMR
3aaa, 7dsa - cCapZ α1+β + myotrophin
7ds2, 7ds4, 7ds6, 7ds8 - cCAPZ α1+β + twinfilin-1
7ds3 - cCAPZ α1+β + twinfilin-2
7ccc - cCAPZ α1+β + twinfilin-1 + ADP
7dsb - cCAPZ α1+β + twinfilin-1 + myotrophin
4akr - CAPZ α1+β – slime mold

ReferencesReferences

  1. ↑ Takeda S, Minakata S, Koike R, Kawahata I, Narita A, Kitazawa M, Ota M, Yamakuni T, Maeda Y, Nitanai Y. Two distinct mechanisms for actin capping protein regulation--steric and allosteric inhibition. PLoS Biol. 2010 Jul 6;8(7):e1000416. PMID:20625546 doi:10.1371/journal.pbio.1000416

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Michal Harel, Alexander Berchansky
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