Fibrinogen: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

David Canner, Angel Herraez, Alexander Berchansky, Michal Harel, Mark Hoelzer

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-<StructureSection load='1n73' size='350' side='right' scene='' caption='Crystal structure of glycosylated fibrinogen fragment D.  Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion (PDB code [[1n73]]) '>
+<StructureSection load='1n73' size='350' side='right' scene='41/410324/Cv/1' caption='Crystal structure of glycosylated fibrinogen fragment D.  Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion (PDB code [[1n73]]) '>
 == Function ==
 '''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing knobs A and B to form fibrin. <ref>PMID:16689770</ref> The fibrin forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. <ref>PMID:18673233</ref>
+==3D Printed Physical Model of Fibrinogen==
+Shown below is a 3D printed physical model of Fibrinogen. The structure is shown as an alpha carbon backbone colored by chain, with the three chains of each copy of fibrinogen colored yellow, blue and purple.
+[[Image:fibrinogen1_centerForBioMolecularModeling.jpg|550px]]
+====The MSOE Center for BioMolecular Modeling====
+[[Image:CbmUniversityLogo.jpg | left | 150px]]
+The [http://cbm.msoe.edu MSOE Center for BioMolecular Modeling] uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our [http://cbm.msoe.edu/educationalmedia/modelgallery/ Model Gallery].
 == Structural insights ==
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 **[[2a45]] - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor<br />
 **[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] - hFba+hFbb+hFbg<br />
-**[[1jy3]], [[1deq]] – cFba+cFbb+cFbg – cow<br />
+**[[1jy3]], [[1deq]] – bFba+Fbb+Fbg – bovine<br />
-**[[1jy2]] - cFba+cFbb+cFbg proteolytic fragment<br />
+**[[1jy2]] - bFba+Fbb+Fbg proteolytic fragment<br />
+**[[1m1j]] - cFba+Fbb+Fbg+peptide ligand – chicken<br />
+**[[1ei3]] - cFba+Fbb+Fbg<br />
 **[[1n73]], [[1lwu]] - Fba+Fbb+Fbg+peptide ligand – Sea lamprey<br />
-**[[1m1j]] - heFba+heFbb+heFbg+peptide ligand – hen<br />
-**[[1ei3]] - heFba+heFbb+heFbg<br />
 *Fibrinogen α chain
@@ Line 32: / Line 46: @@
 **[[1fzd]] – hFba EC domain<br />
 **[[1bbr]] – hFba+cε-thrombin<br />
-**[[2jor]] – cFba – NMR<br />
+**[[2jor]] – bFba – NMR<br />
-**[[2baf]] – cFba<br />
+**[[2baf]] – bFba<br />
 *Fibrinogen β chain
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 *Fibrinogen γ chain
+**[[1fic]], [[1fid]] – hFbg<br />
+**[[3fib]] – hFbg C terminal<br />
 **[[2vr3]] – hFbg+SaClumping Factor A – ''Staphylococcus aureus''<br />
-**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains<br />
+**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+ antibody <br />
 **[[2fib]], [[3fib]] - hFbg+peptide ligand<br />
 **[[1fib]] – hFbg+Ca<br />
-**[[1fic]], [[1fid]] – hFbg<br />
-**[[3fib]] – hFbg C terminal<br />
-**[[1dug]] – Fbg C-terminal/glutathione S-transferase – ''Schistosoma japonicum''<br />
 **[[2hwl]] – hFbg peptide+prothrombin<br />
 **[[2y7l]] – hFbg + agglutinin-like protein <br />
+**[[1dug]] – Fbg C-terminal/glutathione S-transferase – ''Schistosoma japonicum''<br />
 }}
 ==References==