Fibrinogen: Difference between revisions

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[[Image:3hus2.jpg|left|300px|thumb|Crystal Structure of Fibrinogen with peptide ligand, [[3hus]]]]
<StructureSection load='1n73' size='350' side='right' scene='41/410324/Cv/1' caption='Crystal structure of glycosylated fibrinogen fragment D.  Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion (PDB code [[1n73]]) '>


<applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Starting_scene/1" caption= 'Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, [[3hus]]' />
== Function ==


'''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing Knobs A & B to form fibrin. <ref>PMID:16689770</ref> It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained. <ref>PMID:18673233</ref>
'''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing knobs A and B to form fibrin. <ref>PMID:16689770</ref> The fibrin forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. <ref>PMID:18673233</ref>


{{TOC limit|limit=2}}
==3D Printed Physical Model of Fibrinogen==
 
Shown below is a 3D printed physical model of Fibrinogen. The structure is shown as an alpha carbon backbone colored by chain, with the three chains of each copy of fibrinogen colored yellow, blue and purple.
 
[[Image:fibrinogen1_centerForBioMolecularModeling.jpg|550px]]
 
 
====The MSOE Center for BioMolecular Modeling====
 
[[Image:CbmUniversityLogo.jpg | left | 150px]]
 
The [http://cbm.msoe.edu MSOE Center for BioMolecular Modeling] uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our [http://cbm.msoe.edu/educationalmedia/modelgallery/ Model Gallery].
 
 
== Structural insights ==
 
Fibrinogen is composed of 2 copies each of 3 non-identical chains α, β, γ (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene>). 
</StructureSection>


==3D Structure of Fibrinogen==
==3D Structure of Fibrinogen==


Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene> ) . 
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


===Fibrinogen alpha+beta+gamma chains===
*Fibrinogen α+β+γ chains


[[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]] – hFba+hFbb+hFbg+peptide ligand – human <br />
**[[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]] – hFba+hFbb+hFbg+peptide ligand – human<br />
[[3ghg]], [[2q9i]], [[2z4e]] - hFba+hFbb+hFbg+knob A & B<br />
**[[3ghg]], [[2q9i]], [[2z4e]] - hFba+hFbb+hFbg+knob A & B<br />
[[2a45]] - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor<br />
**[[2xnx]], [[2xny]] - hFba+hFbb+hFbg + M1 protein<br />
[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] - hFba+hFbb+hFbg<br />
**[[2a45]] - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor<br />
[[1jy3]], [[1deq]] – cFba+cFbb+cFbg - cow<br />
**[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] - hFba+hFbb+hFbg<br />
[[1n73]], [[1lwu]] - Fba+Fbb+Fbg+peptide ligand – Sea lamprey<br />
**[[1jy3]], [[1deq]] – bFba+Fbb+Fbg – bovine<br />
[[1m1j]] - heFba+heFbb+heFbg+peptide ligand – hen<br />
**[[1jy2]] - bFba+Fbb+Fbg proteolytic fragment<br />
[[1ei3]] - heFba+heFbb+heFbg<br />
**[[1m1j]] - cFba+Fbb+Fbg+peptide ligand – chicken<br />
**[[1ei3]] - cFba+Fbb+Fbg<br />
**[[1n73]], [[1lwu]] - Fba+Fbb+Fbg+peptide ligand – Sea lamprey<br />


===Fibrinogen alpha chain===
*Fibrinogen α chain


[[1fzd]] – hFba EC domain<br />
**[[1fzd]] – hFba EC domain<br />
[[2jor]] – cFba – NMR<br />
**[[1bbr]] – hFba+cε-thrombin<br />
[[2baf]] – cFba<br />
**[[2jor]] – bFba – NMR<br />
**[[2baf]] – bFba<br />


===Fibrinogen beta chain===
*Fibrinogen β chain


[[1fzf]], [[1fzg]] – hFb fragment double-D +peptide ligand<br />
**[[1fzf]], [[1fzg]] – hFb fragment double-D +peptide ligand<br />
[[1fze]], [[1fza]], [[1fzb]] – hFb fragment D<br />
**[[1fze]], [[1fza]], [[1fzb]] – hFb fragment D<br />


===Fibrinogen gamma chain===
*Fibrinogen γ chain
 
[[2vr3]] – hFbg+SaClumping Factor A – Staphylococcus aureus<br />
[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains<br />
[[2fib]], [[3fib]] - hFbg+peptide ligand<br />
[[1fib]] – hFbg+Ca<br />
[[1fic]], [[1fid]] - hFbg<br />


**[[1fic]], [[1fid]] – hFbg<br />
**[[3fib]] – hFbg C terminal<br />
**[[2vr3]] – hFbg+SaClumping Factor A – ''Staphylococcus aureus''<br />
**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+ antibody <br />
**[[2fib]], [[3fib]] - hFbg+peptide ligand<br />
**[[1fib]] – hFbg+Ca<br />
**[[2hwl]] – hFbg peptide+prothrombin<br />
**[[2y7l]] – hFbg + agglutinin-like protein <br />
**[[1dug]] – Fbg C-terminal/glutathione S-transferase – ''Schistosoma japonicum''<br />
}}
==References==
==References==
<references />
<references />
[[Category:Topic Page]]

Latest revision as of 10:16, 28 July 2020


Function

Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing knobs A and B to form fibrin. [1] The fibrin forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. [2]

3D Printed Physical Model of Fibrinogen

Shown below is a 3D printed physical model of Fibrinogen. The structure is shown as an alpha carbon backbone colored by chain, with the three chains of each copy of fibrinogen colored yellow, blue and purple.


The MSOE Center for BioMolecular Modeling

The MSOE Center for BioMolecular Modeling uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our Model Gallery.


Structural insights

Fibrinogen is composed of 2 copies each of 3 non-identical chains α, β, γ (, , ).

Crystal structure of glycosylated fibrinogen fragment D. Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion (PDB code 1n73)

Drag the structure with the mouse to rotate

3D Structure of Fibrinogen3D Structure of Fibrinogen

Updated on 28-July-2020

ReferencesReferences

  1. ↑ Betts L, Merenbloom BK, Lord ST. The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE. J Thromb Haemost. 2006 May;4(5):1139-41. PMID:16689770 doi:10.1111/j.1538-7836.2006.01902.x
  2. ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233

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David Canner, Angel Herraez, Alexander Berchansky, Michal Harel, Mark Hoelzer
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