Transcription initiation factor: Difference between revisions

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<StructureSection load='1vol' size='400' side='right' caption='Structure of human TFIIB (grey) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene=''>
+<StructureSection load='' size='350' side='right' caption='Structure of human TFIIB (cyan) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene='51/517377/Cv/1' pspeed='8'>
-'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process.<br />
+'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br />
 *  '''TFIIA''' is one of several TFs which are required for transcription.  TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA.<br />
-*  '''TFIIB''' bridges between TFIID and RNA polymerase II.<br />
+*  '''TFIIB''' bridges between TFIID and RNA polymerase II<ref>PMID:1876184</ref>.<br />
+*  '''TFIIIB''' is the core RNA polymerase III initiation factor.  It recruits pol III to the transcriptional start site<ref>PMID:17073756</ref>.<br />
 *  '''TFIID''' recognizes the promoter sequence on the DNA.<br />
-*  '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.
+*  '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br />
+*  '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.<br />
+*  '''TF RRN''' initiate transcription by RNA polymerase I in yeast.<ref>PMID:8670901</ref><br />
+<scene name='51/517377/Cv/3'>Human TFIIB complex with TATA-binding protein and DNA</scene> (PDB entry [[1vol]]).
 ==3D structures of transcription initiation factors==
+[[Transcription initiation factors 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-===TFIIA===
+== References ==
+<references/>
-[[1ytf]], [[1nh2]], [[1rm1]] – yTFIIA + TBP + DNA – yeast<br />
-[[1nvp]] – hTFIIA + TATA-binding protein + DNA – human<br />
-===TFIIB===
-[[1pft]] – TFIIB N terminal – ''Pyrococcus furiosus'' – NMR<BR />
-[[1tfb]] – hTFIIB - NMR<BR />
-[[1dl6]] - hTFIIB N terminal – NMR<br />
-[[1rly]] - hTFIIB Zn ribbon domain + Zn – NMR<br />
-[[1ro4]] - hTFIIB Zn ribbon domain – NMR<br />
-[[1vol]], [[1c9b]]  – hTFIIB + TBP + DNA<BR />
-[[3k1f]], [[3k7a]], [[4bbr]], [[4bbs]] – yTFIIB + RNA polymerase II<br />
-[[1ais]], [[1d3u]] - TFIIB C terminal + TBP + DNA – ''Pyrococcus woesei''
-===TFIID===
-[[1bh8]] – hTFIID<BR />
-[[1eqf]] – hTFIID subunit 1<br />
-[[3uv5]], [[3uv4]] – hTFIID subunit 1 bromodomain <br />
-[[3aad]] – hTFIID subunit 1 bromodomain + histone chaperone ASF1A<br />
-[[1tba]] – TFIID – ''Drosophila melanogaster'' - NMR<BR />
-[[1bh9]] – hTFIID + PCMBS<BR />
-[[1qn3]], [[1qn4]], [[1qn5]], [[1qn6]], [[1qn7]], [[1qn8]], [[1qn9]], [[1qna]], [[1qnb]], [[1qnc]], [[1qne]] – TFIID + DNA – ''Arabidopsis thaliana''
-'''TFIIE'''
-[[1vd4]] - hTFIIB Zn finger domain – NMR<br />
-[[2rnq]] – hTFIIE C terminal - NMR<br />
-[[2rnr]] – hTFIIE C terminal + TFIIH PH domain- NMR<br />
-'''TFIIF'''
-[[1f3u]] – hTFIIF<br />
-[[1nha]] – hTFIIF C terminal - NMR<br />
-[[1i27]] – hTFIIF C terminal (mutant)<br />
-[[1j2x]] – hTFIIF C terminal + RNA polymerase CTD phosphatase peptide<br />
-[[1onv]] – hTFIIF C terminal + serine phosphatase peptide - NMR<br />
-[[2k7l]] – hTFIIF C terminal + FCP1 peptide - NMR<br />
-</StructureSection>
 [[Category:Topic Page]]