Transcription initiation factor: Difference between revisions

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<StructureSection load='1vol' size='400' side='right' caption='Structure of human TFIIB complex with TATA-binding protein and DNA (PDB entry [[1vol]])' scene=''>
+<StructureSection load='' size='350' side='right' caption='Structure of human TFIIB (cyan) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene='51/517377/Cv/1' pspeed='8'>
-'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process.  TFIID recognizes the promoter sequence on the DNA while TFIIB bridges between TFIID and RNA polymerase II.  TFIIA is one of several TFs which are required for transcription.  TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA.
+'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br />
+*  '''TFIIA''' is one of several TFs which are required for transcription.  TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA.<br />
+*  '''TFIIB''' bridges between TFIID and RNA polymerase II<ref>PMID:1876184</ref>.<br />
+*  '''TFIIIB''' is the core RNA polymerase III initiation factor.  It recruits pol III to the transcriptional start site<ref>PMID:17073756</ref>.<br />
+*  '''TFIID''' recognizes the promoter sequence on the DNA.<br />
+*  '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br />
+*  '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.<br />
+*  '''TF RRN''' initiate transcription by RNA polymerase I in yeast.<ref>PMID:8670901</ref><br />
+<scene name='51/517377/Cv/3'>Human TFIIB complex with TATA-binding protein and DNA</scene> (PDB entry [[1vol]]).
 ==3D structures of transcription initiation factors==
+[[Transcription initiation factors 3D structures]]
-===TFIIA===
+</StructureSection>
-[[1ytf]] – TFIIA + TBP + DNA – yeast
-===TFIIB===
-[[1pft]] – TFIIB N terminal – ''Pyrococcus furiosus'' – NMR<BR />
-[[1tfb]] – hTFIIB – human - NMR<BR />
-[[1vol]], [[1c9b]]  – hTFIIB + TBP + DNA<BR />
-[[1ais]], [[1d3u]] - TFIIB C terminal + TBP + DNA – ''Pyrococcus woesei''
-===TFIID===
-[[1bh8]] – hTFIID<BR />
-[[1tba]] – TFIID – ''Drosophila melanogaster'' - NMR<BR />
-[[1bh9]] – hTFIID + PCMBS<BR />
-[[1qn3]], [[1qn4]], [[1qn5]], [[1qn6]], [[1qn7]], [[1qn8]], [[1qn9]], [[1qna]], [[1qnb]], [[1qnc]] – TFIID + DNA – ''Arabidopsis thaliana''
+== References ==
+<references/>
-</StructureSection>
 [[Category:Topic Page]]