Transcription initiation factor: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='1vol' size='400' side='right' caption='Structure of human TFIIB complex with TATA-binding protein and DNA (PDB entry 1vol)' scene=''> '''Transcription initiat... |
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<StructureSection load='' size='350' side='right' caption='Structure of human TFIIB (cyan) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene='51/517377/Cv/1' pspeed='8'> | |||
'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br /> | |||
* '''TFIIA''' is one of several TFs which are required for transcription. TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA.<br /> | |||
'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process. | * '''TFIIB''' bridges between TFIID and RNA polymerase II<ref>PMID:1876184</ref>.<br /> | ||
* '''TFIIIB''' is the core RNA polymerase III initiation factor. It recruits pol III to the transcriptional start site<ref>PMID:17073756</ref>.<br /> | |||
* '''TFIID''' recognizes the promoter sequence on the DNA.<br /> | |||
* '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br /> | |||
* '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.<br /> | |||
* '''TF RRN''' initiate transcription by RNA polymerase I in yeast.<ref>PMID:8670901</ref><br /> | |||
<scene name='51/517377/Cv/3'>Human TFIIB complex with TATA-binding protein and DNA</scene> (PDB entry [[1vol]]). | |||
==3D structures of transcription initiation factors== | ==3D structures of transcription initiation factors== | ||
[[Transcription initiation factors 3D structures]] | |||
</StructureSection> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | |||
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Latest revision as of 11:52, 4 March 2020
Transcription initiation factors (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process[1][2].
(PDB entry 1vol). 3D structures of transcription initiation factorsTranscription initiation factors 3D structures
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ReferencesReferences
- ↑ Roeder RG. The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem Sci. 1996 Sep;21(9):327-35. PMID:8870495
- ↑ Kuhlman TC, Cho H, Reinberg D, Hernandez N. The general transcription factors IIA, IIB, IIF, and IIE are required for RNA polymerase II transcription from the human U1 small nuclear RNA promoter. Mol Cell Biol. 1999 Mar;19(3):2130-41. PMID:10022900
- ↑ Ha I, Lane WS, Reinberg D. Cloning of a human gene encoding the general transcription initiation factor IIB. Nature. 1991 Aug 22;352(6337):689-95. PMID:1876184 doi:http://dx.doi.org/10.1038/352689a0
- ↑ Kassavetis GA, Geiduschek EP. Transcription factor TFIIIB and transcription by RNA polymerase III. Biochem Soc Trans. 2006 Dec;34(Pt 6):1082-7. doi: 10.1042/BST0341082. PMID:17073756 doi:http://dx.doi.org/10.1042/BST0341082
- ↑ Peterson MG, Inostroza J, Maxon ME, Flores O, Admon A, Reinberg D, Tjian R. Structure and functional properties of human general transcription factor IIE. Nature. 1991 Dec 5;354(6352):369-73. PMID:1956398 doi:http://dx.doi.org/10.1038/354369a0
- ↑ Yamamoto RT, Nogi Y, Dodd JA, Nomura M. RRN3 gene of Saccharomyces cerevisiae encodes an essential RNA polymerase I transcription factor which interacts with the polymerase independently of DNA template. EMBO J. 1996 Aug 1;15(15):3964-73. PMID:8670901