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| [[Image: Nexium.jpg|300px|right|thumb| AstraZeneca’s Nexium]]
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| {{#tree:id=siteTree| | | {{#tree:id=siteTree| |
| <big>The following is a list of major pharmaceutical compound targets, drugs, and information organized by disease. </big> | | <big>The following is a list of major pharmaceutical compound targets, drugs, and information organized by disease. </big> |
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| **Alzheimer’s Disease | | **Alzheimer’s Disease |
| ***[[Acetylcholine]] | | ***See: [[Alzheimer's Disease]] |
| ***[[Acetylcholinesterase]]
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| ***[[2ace|Acetylcholinesterase from Torpedo Californica]]
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| ***[[SANDBOX138|Human APP Intracellular Domain Complex with Fe65-PTB2]]
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| ***[[Flexibility of aromatic residues in acetylcholinesterase|Aromatic Residue Flexibility in AChE]]
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| ***[[Beta Amyloid]]
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| ***[[Acetylcholine binding protein]] (AChBP)
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| ***[[Butyrylcholinesterase]] (BChE)
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| ***Drug Compounds & Substrates
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| ****[[AChE_bivalent_inhibitors|Bivalent Inhibitors of Acetylcholinesterase]]
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| ****[[AChE_bivalent_inhibitors_%28Part_II%29|Bivalent Inhibitors of Acetylcholinesterase, Part II]]
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| ****[[AChE_inhibitors_and_substrates|Inhibitors and Substrates of Acetylcholinesterase]]
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| ****[[ AChE_inhibitors_and_substrates_%28Part_II%29|Inhibitors and Substrates of Acetylcholinesterase, Part II]]
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| ****[[ AChE_inhibitors_and_substrates_%28Part_III%29|Inhibitors and Substrates of Acetylcholinesterase, Part III]]
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| ****Specific Examples:
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| *****[[1eve|Aricept Complexed with Acetylcholinesterase]]
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| *****[[2dfp|DFP (Aged) Complexed with Acetylcholinesterase]]
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| *****[[1ax9|Edrophonium Complexed with Acetylcholinesterase]] or [[2ack|Here]]
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| *****[[2j3q|Fluorophore Thioflavin T Complexed with Acetylcholinesterase]]
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| *****[[1dx6|Galanthamine Complexed with Acetylcholinesterase]]
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| *****[[1vot|Huperzine A Complexed with Acetylcholinesterase]]
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| *****[[1w6r|Iminium Galanthamine Derivative bound to Acetylcholinesterase]] or [[1w4l|Here]], or [[1w76|Here]].
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| *****[[1gqs|NAP Complexed with Acetylcholinesterase]]
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| *****[[1vxr|O-tthylmethylphosphonylated Acetylcholinesterase]]
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| *****[[2wfz|Soman Complexed with Acetylcholinesterase]] or [[2wg0|Here]], or [[2wg1|Here]], or [[1cfj|Here]], or [[1som|Here]].
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| *****[[1acj|Tacrine Complexed with Acetylcholinesterase]]
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| **** Bivalent Inhibitors
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| *****[[1u65|Anticancer Prodrug CPT-11 Complexed with Acetylcholinesterase]]
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| *****[[1eve|Aricept Complexed with Acetylcholinesterase]]
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| *****[[1w4l|Bis-Acting Galanthamine Derivative Complexed with Acetylcholinesterase]], or [[1w76|Here]], or [[1w6r|Here]]
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| *****[[2cmf|Bis-Tacrine Derivative Complexed with Acetylcholinesterase]] or [[2ckm|Here]] or [[1odc|Here]]
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| *****[[1acl|Bisquaternary Decamethonium Complexed with Acetylcholinesterase]]
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| *****[[1e3q|BW284C51 Complexed with Acetylcholinesterase]]
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| *****[[1zgb|Hupyridone Derivative Complexed with Acetylcholinesterase]], or [[1zgc|Here]], or [[1h22|Here]], or [[1h23|Here]]
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| *****[[1ut6|N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE Complexed with Acetylcholinesterase]]
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| *****[[1jjb|PEG-SH Complexed with Acetylcholinesterase]]
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| ***[[Gamma-Secratase]]
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| ***Glutamate Receptor
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| ****[[Glutamate receptor (GluA2)]]
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| ****[[Molecular_Playground/Glutamate_Receptor|Glutamate Receptor]]
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| **Anemia | | **Anemia |
| ***[[Erythropoietin]] | | ***[[Erythropoietin]] |
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| | **Antifungal |
| | ***[[Noxafil]] |
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| | **Antimalarial |
| | ***[[Malarial Dihydrofolate Reductase as Drug Target]] |
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| | **Anti-parasitic |
| | ***[[Ivermectin|Drug: Ivermectin; Target: Glutamate-gated chloride channels]] |
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| **Asthma and other Pulmonary Disease States | | **Asthma and other Pulmonary Disease States |
| ***[[Beta-2-Andrenergic Receptor]] | | ***[[Beta-2 Adrenergic Receptor]] |
| ***[[Leukotriene Receptor]] | | ***[[Leukotriene Receptor]] |
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| **Autoimmune Diseases | | **Autoimmune Diseases |
| ***[[Tumor Necrosis Factor Receptor]] | | ***[[Prolyl Endopeptidase]] |
| | ***[[Tumor necrosis factor receptor]] |
| ***[[Molecular_Playground/TRAIL|Tumor-Necrosis Factor Apoptosis-Inducing Ligand]] | | ***[[Molecular_Playground/TRAIL|Tumor-Necrosis Factor Apoptosis-Inducing Ligand]] |
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| **Bacterial Infections | | **Bacterial Infections |
| ***[[Gyrase]] - Target of the Quinolones | | *** See: [[Bacterial Infections]] |
| ***[[User:Wayne Decatur/Interactions between Antibiotics and the Ribosome|Interactions between Antibiotics & the Ribosome]]
| | ***[[Treatment of Tuberculosis]] |
| ***[[Large Ribosomal Subunit of Haloarcula|Large Ribosomal Subunit]] | |
| ***[[User:Wayne Decatur/Haloarcula Large Ribosomal Subunit With Azithromycin|Large Ribosomal Subunit with Azithromycin]]
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| ***[[Molecular_Playground/PcrA_Helicase|PcrA Helicase]]
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| **Blood Clots, Haemophilia, & Thrombic Events | | **Blood Clots, Haemophilia, & Thrombic Events |
| ***[[P2Y12]] | | ***[[P2Y12]] |
| ***Haemophilia | | ***Haemophilia |
| ****[[Jolanta_amblo|Factor VII]] | | **** See: [[Hemophilia]] |
| ****[[Factor_IX|Factor IX]]
| | ***[[Platelet-receptor glycoprotein Ib alpha]] |
| ****[[User:Nadia_Dorochko|Factor IX Information]]
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| ****[[Conformation-specific anti-Factor IX antibodies|Factor IX Bound to Antibody]]
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| ****[[Factor_Xa|Factor Xa]]
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| **Cancer | | **Cancer |
| ***[[Antizyme Inhibitor]] | | *** See: [[Cancer]] |
| ***Caspases
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| ****[[Molecular_Playground/Caspase-6|Caspase-6]]
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| ****[[Molecular_Playground/Caspase-7_Dynamics|Caspase-7 Dynamics]]
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| ****[[Molecular_Playground/Caspase-9_Regulation|Caspase-9 Regulation]]
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| ***[[User:Greg_Black/Sandbox_1|Cisplatin Information]]
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| ***[[Michael Purol Sandbox 1|Cyclin Dependent Kinase Inhibitor]]
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| ***[[NADPH Cytochrome P450 Oxidoreductase|Cytochrome P450 Oxidoreductase]]
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| ***[[6-deoxyerythronolide_B_synthase_%28DEBS%29|DEBS]]
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| ***[[Dihydrofolate_reductase|Dihydrofolate Reductase, the Target of Methotrexate]]
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| ***[[Farnesoid X Receptor]]
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| ***Growth Factors & Receptors
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| ****Epidermal Growth Factor
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| *****[[Epidermal Growth Factor]]
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| *****[[Epidermal Growth Factor Receptor]]
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| ****[[Hepatocyte Growth Factor Receptor]]
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| ****[[Human Epidermal Growth Factor Receptor 2]]
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| ****Insulin-Like Growth Factor
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| *****[[Insulin-Like Growth Factor-1]]
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| *****[[Insulin-Like Growth Factor-1 Receptor]]
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| ****Vascular Growth Factor
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| *****[[Vascular Endothelial Growth Factor]]
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| *****[[Vascular Endothelial Growth Factor Receptor]]
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| ***[[Molecular_Playground/FIH|Hypoxia Inducible Factor (HIF)]]
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| ***[[User:Yash_Patankar/Sandbox_1|Heat Shock Protein 90]]
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| ***[[1ebm|Human 8-Oxoguanine Glycosylase Structure and Mechanism (HOGG1)]]
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| ***Kinases
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| ****[[Cory_Tiedeman_sandbox|Cyclin Dependent Kinase-4]]
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| ****[[Cell Division Cycle 7-Related Protein Kinase]]
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| ****[[Mammalian Target of Rapamycin]]
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| ****Mitogen-Activated Proteins
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| *****Mitogen-Activated Protein Kinase
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| *****Mitogen-Activated Protein Kinase Kinase
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| *****Mitogen-Activated Protein Kinase Kinase Kinase
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| ******[[c-Raf]]
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| ****[[Phosphatidylinositol 3-Kinase]]
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| ****[[SRC]]
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| ***[[P-glycoprotein:_Why_Cancer_Drugs_Fail|P-Glycoprotein: Why Cancer Drugs Fail]]
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| ***Oncogenes
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| ****[[C-Myc]] - Proto-Oncogenic Gene
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| ****[[P53]] - Tumor Suppressing Gene
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| ****[[Matt Routh sandbox|MDM2 Bound to p53]]
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| ****[[SRC]] - Proto-Oncogenic Tyrosine Kinase Gene
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| ***[[Ann_Taylor_sandbox_Proteins_in_Cancer|Proteins in Cancer]]
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| ***[[Ras|Ras Superfamily]]
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| ***[[Chad Sorenson sandbox 1|Retinoblastoma Protein]]
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| ***[[Molecular_Playground/Taxol|Taxol Information]]
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| ***[[Molecular_Playground/TRAIL|Tumor-Necrosis Factor Apoptosis-Inducing Ligand]]
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| ***[[Molecular_Playground/YKL-40|YKL-40]]
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| **Compromised Immune System | | **Compromised Immune System |
| ***[[Granulocyte-macrophage colony-stimulating factor]] | | ***[[Granulocyte-macrophage colony-stimulating factor]] |
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| **Delivery Systems | | **Delivery Systems & Biotech |
| ***[[Molecular_Playground/Targeting_Peptide|Targeted Drug Delivery]] | | ***[[Molecular_Playground/Targeting_Peptide|Targeted Drug Delivery]] |
| | ***[[Monoclonal Antibody]] |
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| **Diabetes & Hypoglycemia | | **Diabetes & Hypoglycemia |
| ***[[Molecular_Playground/Insulin|Insulin Information]] | | *** See: [[Diabetes]] |
| ***[[Sandbox 67|Insulin Structure]]
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| ***[[User:Mary Ball/Leptin|Leptin]]
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| ***[[Peroxisome Proliferator-Activated Receptors]]
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| ***[[Molecular_Playground/YKL-40|YKL-40]]
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| **Digestive Diseases | | **Digestive Diseases |
| ***[[Proton Pump]] | | ***Proton Pump |
| | ****[[Esomeprazole and H+/K+ - ATPase Interaction]] |
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| **Erectile Dysfunction | | **Erectile Dysfunction |
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| **Hypertension & Congestive Heart Failure | | **Hypertension & Congestive Heart Failure |
| ***[[Angiotensin-Converting Enzyme]] | | ***See: [[Hypertension & Congestive Heart Failure]] |
| ***[[Calcium Channel]]
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| **Inflammation & Rheumatoid Arthritis | | **Inflammation & Rheumatoid Arthritis |
| ***[[Cyclooxygenase]] | | ***[[Inflammation & Rheumatoid Arthritis]] |
| ***[[Aspirin effects on COX aka PGHS|Asprin Effects on Cyclooxygenase]]
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| ***[[Sandbox 165|Interleukin-10]]
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| ***[[Molecular_Playground/YKL-40|YKL-40]]
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| **Metabolic Disorders | | **Metabolic Disorders |
| ***[[Acid-beta-glucosidase]] | | *** See: [[Metabolic Disorders]] |
| ***[[Molecular_playground/beta_2_microglobulin|ß-2 Microglobulin]]
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| ***[[Molecular_Playground/Human_PPCA|Protective Protein/Cathepsin A (PPCA)]]
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| ***[[Molecular_Playground/Human_Protective_Protein_Cathepsin_A|Protective Protein/Cathepsin A (PPCA) 2]]
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| ***[[Bacterial thiolase|Thiolase]]
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| ***[[Treatment_of_Gaucher_disease]]
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| ***[[Molecular_Playground/Velaglucerase|Velaglucerase]]
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| ***[[Disulfide Connectivity of Velaglucerase|Velaglucerase Disulfide Connectivity]]
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| **Schizophrenia, Bipolar Depression, Insomnia, and Anxiety Disorders | | **Schizophrenia, Bipolar Depression, Depression, Insomnia, and Anxiety Disorders |
| ***[[Dopamine Receptor]] | | ***[[Dopamine receptor]] |
| ***[[Andrenergic Receptor]] | | ***[[Adrenergic receptor]] |
| ***[[Histamine Receptor]] | | ***[[Histamine H1 receptor]] |
| ***[[Opioid Receptor]] | | ***[[Opioid receptor]] |
| | ***[[5-hydroxytryptamine receptor]] |
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| **Viral Infection | | **Viral Infection |
| ***[[Molecular_Playground/T7_RNA_Polymerase_%287_mer_int%29| T7 RNA Polymerase]] | | ***[[Molecular_Playground/T7_RNA_Polymerase_%287_mer_int%29| T7 RNA Polymerase]] |
| *** HIV | | *** HIV |
| ****[[User:Eric Martz/Molecular Playground/HIVDrug|HIV-1 Drug]] | | **** See: [[Human Immunodeficiency Virus]] |
| ****[[HIV-1 protease|HIV-1 Protease]]
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| ****[[User:Tsung-Yi_Lin/Sandbox|HIV-1 Protease Analysis]]
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| ****[[HIV-1 Gag]]
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| ****[[1gwp|HIV-1 Gag N-terminal Domain]]
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| ****[[HIV-1 Gag Recruitment of Tsg101 and the Viral Budding Process]]
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| ****[[HIV-1 NEF]]
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| ****[[Molecular_Playground/HIV_Protease_Inhibitor|HIV-1 Protease Inhibitor]]
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| ****[[HIV-1_Subtype_C_Protease|HIV-1 Subtype C Protease]]
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| ****[[Reverse Transcriptase]]
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| *** Influenza | | *** Influenza |
| **** [[Avian Influenza Neuraminidase, Tamiflu and Relenza]] | | **** See: [[Influenza]] |
| **** [[Avian Influenza Neuraminidase, Tamiflu and Relenza]]
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| **** H1N1 Sequence Analyses
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| ****** [[User:Michael_Strong/H1N1|H1N1 Swine Flu Sequence Analysis]]
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| ****** [[User:Michael_Strong/H1N1/MP1/MSA|H1N1 Swine Flu Multiple Sequence Alignment]]
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| ****** [[User:Michael Strong/H1N1/MP2/MSA|H1N1 Sequence Alignment of MP2 Protein]]
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| ****** [[User:Michael_Strong/H1N1/PB2|H1N1 Sequence Alignment of PB2 Protein]]
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| ****** [[User:Michael_Strong/H1N1/PB1|H1N1 Sequence Alignment of PB1 Protein]]
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| ****** [[User:Michael_Strong/H1N1/NS2/MSA|H1N1 Sequence Alignment of NS2 Protein]]
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| ****** [[User:Michael_Strong/H1N1/PA|H1N1 Sequence Alignment of PA Protein]]
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| ****** [[User:Michael_Strong/H1N1/HA|H1N1 Sequence Alignment of HA Protein]]
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| ****** [[User:Michael_Strong/H1N1/NP|H1N1 Sequence Alignment of NP Protein]]
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| ****** [[User:Michael_Strong/H1N1/NA|H1N1 Sequence Alignment of NA Protein]]
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| ****** [[User:Michael_Strong/H1N1/MP|H1N1 Sequence Alignment of MP Protein]]
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| ****** [[User:Michael_Strong/H1N1/NS|H1N1 Sequence Alignment of NS Protein]]
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| **** [[SAndbox_159|Hemagglutinins]]
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| **** [[Influenza hemagglutinin]]
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| **** [[Molecular_Playground/Influenza_A_M2_transmembrane_domain|Influenza A M2 Transmembrane Domain]]
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| **** [[Proton Channels]] featuring a morph of the M2 proton channel of influenza.
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| **** [[Molecular Playground/Tamiflu|Tamiflu]]
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| **** [[Molecular Playground/Relenza|Relenza]]
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| *** [[Herpes Simplex Virus Thymidine Kinase]] | | *** [[Herpes Simplex Virus Thymidine Kinase]] |
| *** [[NS5B|RNA Dependent RNA Polymerase from Hepatitis C Virus]] | | *** [[NS5B|RNA Dependent RNA Polymerase from Hepatitis C Virus]] |
| | *** Poliovirus |
| | ****[[Journal:PLoS ONE:1|Antiviral Activity of 3(2H)- and 6-Chloro-3(2H)-Isoflavenes against Highly Diverged, Neurovirulent Vaccine-Derived, Type2 Poliovirus Sewage Isolates]] |
| | *** [[Interferon]] |
| }} | | }} |
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| | See [[Pharmaceutical Drugs]] for descriptions and analysis of well known drugs |