Platelet glycoprotein

Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain Publication Abstract from PubMed Transient interactions of platelet-receptor glycoprotein Ibalpha (GpIbalpha) and the plasma protein von Willebrand factor (VWF) reduce platelet velocity at sites of vascular damage and play a role in haemostasis and thrombosis. Here we present structures of the GpIbalpha amino-terminal domain and its complex with the VWF domain A1. In the complex, GpIbalpha wraps around one side of A1, providing two contact areas bridged by an area of solvated charge interaction. The structures explain the effects of gain-of-function mutations related to bleeding disorders and provide a model for shear-induced activation. These detailed insights into the initial interactions in platelet adhesion are relevant to the development of antithrombotic drugs. Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain., Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, Gros P, Science. 2002 Aug 16;297(5584):1176-9. PMID:12183630 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. Platelet glycoprotein Ib alpha has a role in the adhesion and migration of leukocytes on vascular thrombus. Platelet glycoprotein 4 or CD36 functions as a receptor for thrombospondin and collagen . Platelet glycoprotein 6 ha a role in collagen-induced platelet activation. Disease Known disease associated with this structure: von Willebrand disease, autosomal dominant OMIM:[193400], von Willebrand disease, autosomal recessive OMIM:[193400], Bernard-Soulier syndrome, benign autosomal dominant OMIM:[606672], Bernard-Soulier syndrome, type A OMIM:[606672], von Willebrand disease, platelet-type OMIM:[606672], Nonarteritic anterior ischemic optic neuropathy, susceptibility to OMIM:[606672] About this Structure 1m10 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

spinqualitylabelsall models Platelet-receptor glycoprotein Ib alpha (blue) involved in Willebrand disease bound to the von Willebrand Factor A1 Domain (green surface), (1m10) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of platelet glycoprotein3D structures of platelet glycoprotein

Updated on 21-July-2024

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• Platelet glycoprotein Ib
  • 1gwb, 1p9a, 1qyy – hPGIb von Willenbrand factor binding domain 17-306 - human
    
  • 1m0z – hPGIb von Willenbrand factor binding domain (mutant)
    
  • 3rfe – hPGIb b chain 26-146
    
  • 3rfe – hPGIb b chain 26-146 (mutant)
    
  • 6ejx – PGIb a chain von Willenbrand factor binding domain - mouse
    
• Platelet glycoprotein Ib complexes
  • 1m10, 1sq0 – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain (mutant)
    
  • 6xfq – hPGIb von Willenbrand factor binding domain + agkisacucetin
    
  • 1u0n – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain + botrocetin
    
  • 3pmh, 1gwb – hPGIb von Willenbrand factor binding domain (mutant) + thrombin
    
  • 1p8v – hPGIb von Willenbrand factor binding domain (mutant) + prothrombin
    
  • 1sq0 – hPGIb von Willenbrand factor binding domain + peptide inhibitor
    
  • 2bp3 – hPGIb cytoplasmic domain + filamin A rod domain
    
  • 1ook – hPGIb a chain + alpha thrombin + peptide
    
  • 4c2a, 4c2b – hPGIb a chain (mutant) + von Willenbrand factor
    
  • 3p72 – hPGIb a chain + peptide inhibitor
    
• Platelet glycoprotein 4
  • 5lgd – hPG4 + PFEMP1
    
• Platelet glycoprotein 6
  • 2gi7, [5ou7]] – hPG6
    
  • 5ou9, 5ou8 – hPG6 + collagen peptide
    
  • 7nmu – hPG6 + nanobody
    
  • 7r58 – hPG6 + antibody
    

See AlsoSee Also

• Leucine-rich repeat
• Variable lymphocyte receptor
• Lamprey Variable Lymphocyte Receptor
• Diseases