Profilin: Difference between revisions

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<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (pale green),  VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code [[2pbd]])' scene=''>
<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (grey),  VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code [[2pbd]])' scene=''>
== Function ==
== Function ==
'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin.  PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>.  PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers.  '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney.  PFN was found in all eukaryotes.
'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin.  PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>.  PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers.  '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney.  PFN was found in all eukaryotes.
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PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>.
PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>.
</StructureSection>


== 3D Structures of profilin ==
== 3D Structures of profilin ==
[[Profilin 3D Structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Profilin I
 
**[[1fik]], [[1fil]], [[4x1l]] – hPFN – human <br />
**[[1pfl]] – hPFN - NMR  <br />
**[[4x25]], [[4x1m]] – hPFN (mutant)  <br />
**[[1pne]] – bPFN – bovine  <br />
**[[1cqa]] – PFN - birch  <br />
**[[3nul]], [[1a0k]] – PFN – ''Arabidopsis thaliana''  <br />
**[[1ypr]], [[1k0k]] – PFN - yeast  <br />
**[[3d9y]], [[3dav]] – PFN – fission yeast <br />
**[[1g5u]] – PFN – ''Hevea brasiliensis'' <br />
**[[2jkf]] – PfPFN – ''Plasmodium falciparum''  <br />
**[[4esp]] – PFN – peanut <br />
**[[4qwo]] – PFN – monkeypox virus <br />
**[[2prf]] – AcPFN – ''Acanthamoeba castellanii''  - NMR<br />
**[[1prq]] – AcPFN <br />
**[[3nec]] – PFN – ''Toxoplasma gondii''<br />
 
*Profilin I complex
 
**[[2btf]], [[3u4l]], [[3ub5]] – bPFN + β-actin  <br />
**[[1hlu]] – bPFN + β-actin  + ATP <br />
**[[2jkg]] – PfPFN + poly-Pro peptide  <br />
**[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide  <br />
**[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide + ATP <br />
 
*Profilin II
 
**[[1acf]], [[2acg]], [[1f2k]] – AcPFN  <br />
**[[1d1j]] – hPFN  <br />
**[[2vk3]] – PFN - rat <br />
**[[2v8c]] – mPFN + VASP poly-Pro peptide - mouse  <br />
**[[2v8f]] – mPFN + MDIA1 poly-Pro peptide  <br />


}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]

Latest revision as of 13:43, 27 November 2019

Function

Profilin (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin[1]. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes.

Disease

PFN from birch, peanut and other plants is a major allergen[2].

3D Structures of profilin

Profilin 3D Structures


Human profilin I (green) complex with α-actin (grey), VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code 2pbd)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Nejedla M, Sara S, Sulimenko V, de Almeida FN, Blom H, Draber P, Aspenstrom P, Karlsson R. Profilin connects Actin Assembly with Microtubule dynamics. Mol Biol Cell. 2016 Jun 15. pii: mbc.E15-11-0799. PMID:27307590 doi:http://dx.doi.org/10.1091/mbc.E15-11-0799
  2. ↑ Alvarado MI, Jimeno L, De La Torre F, Boissy P, Rivas B, Lazaro MJ, Barber D. Profilin as a severe food allergen in allergic patients overexposed to grass pollen. Allergy. 2014 Dec;69(12):1610-6. doi: 10.1111/all.12509. Epub 2014 Oct 3. PMID:25123397 doi:http://dx.doi.org/10.1111/all.12509

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Michal Harel
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