Profilin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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-<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (pale green),  VASP protein poly-Pro peptide (olive), ATP (stick model) and Ca+2 ion (PDB code [[2pbd]])' scene=''>
+<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (grey),  VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code [[2pbd]])' scene=''>
 == Function ==
 '''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin.  PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>.  PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers.  '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney.  PFN was found in all eukaryotes.
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 PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>.
-</StructureSection>
 == 3D Structures of profilin ==
+[[Profilin 3D Structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Profilin I
-**[[1fik]], [[1fil]], [[4x1l]] – hPFN – human <br />
-**[[1pfl]] – hPFN - NMR  <br />
-**[[4x25]], [[4x1m]] – hPFN (mutant)  <br />
-**[[1pne]] – bPFN – bovine  <br />
-**[[1cqa]] – PFN - birch  <br />
-**[[3nul]], [[1a0k]] – PFN – ''Arabidopsis thaliana''  <br />
-**[[1ypr]], [[1k0k]] – PFN - yeast  <br />
-**[[3d9y]], [[3dav]] – PFN – fission yeast <br />
-**[[1g5u]] – PFN – ''Hevea brasiliensis'' <br />
-**[[2jkf]] – PfPFN – ''Plasmodium falciparum''  <br />
-**[[4esp]] – PFN – peanut <br />
-**[[4qwo]] – PFN – monkeypox virus <br />
-**[[2prf]] – AcPFN – ''Acanthamoeba castellanii''  - NMR<br />
-**[[1prq]] – AcPFN <br />
-**[[3nec]] – PFN – ''Toxoplasma gondii''<br />
-*Profilin I complex
-**[[2btf]], [[3u4l]], [[3ub5]] – bPFN + β-actin   <br />
-**[[1hlu]] – bPFN + β-actin  + ATP <br />
-**[[2jkg]] – PfPFN + poly-Pro peptide   <br />
-**[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide   <br />
-**[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide + ATP <br />
-*Profilin II
-**[[1acf]], [[2acg]], [[1f2k]] – AcPFN  <br />
-**[[1d1j]] – hPFN  <br />
-**[[2vk3]] – PFN - rat <br />
-**[[2v8c]] – mPFN + VASP poly-Pro peptide - mouse  <br />
-**[[2v8f]] – mPFN + MDIA1 poly-Pro peptide  <br />
-}}
 == References ==
 <references/>
+[[Category:Topic Page]]