Methylesterase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-{{STRUCTURE_3uw0|  PDB=3uw0  | SIZE=400| SCENE= |right|CAPTION=Pectin methylesterase [[3uw0]] }}
+<StructureSection load='3c5w' size='350' side='right' caption='Human protein phosphatase methylesterase (green) complex with protein phosphatase 2A subunit A (cyan) and subunit C (magenta) (PDB entry [[3c5w]])' scene='48/489289/Cv/1'>
+__TOC__
+== Function ==
 '''Methylesterase''' (ME) removes a methyl group from the Υ-glutamyl methyl esther residues of methyl-accepting chemotaxis proteins.  ME participates in several metabolic pathways.  <br />
 *  '''CheB ME''' is a phosphorylation-activated response regulator involved in reversible modification of bacterial chemotaxis receptors<ref>PMID:2991277</ref>.  See [[Chemotaxis protein]].<br />
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 *  '''Protein phosphatase ME''' is involved in the reversible methylation of protein phosphatase 2A which is active in cellular regulation<ref>PMID:24928782</ref>.<br />
 *  '''4-o-methyl-glucuronoyl ME''' has a significant role in biomass degradation<ref>PMID:16876163</ref>.<br />
+== Structural highlights ==
+*<scene name='48/489289/Cv/6'>Human protein phosphatase methylesterase with protein phosphatase 2A subunits A and C</scene>.
+*<scene name='48/489289/Cv/5'>Protein phosphatase ME binds to the active site of subunit C of phospholipase 2A</scene>.  It inactivates phospholipase 2A by interacting with the latter's subunit C by removing two catalytic Mn+2 ions from it<ref>PMID:18394995</ref>.
 ==3D structures of methylesterase==
+[[Methylesterase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Pectin methylesterase
-**[[1qjv]] – EcME – ''Erwinia chrysanthemi''<br />
-**[[1gq8]] – ME – carrot<br />
-**[[3uw0]] – ME – ''Yersinia enterocolitica''<br />
-**[[1xg2]] – ME + protein inhibitor – ''Solanum lycopersicum''<br />
-**[[2nsp]], [[2nst]], [[2nt6]], [[2nt9]] – EcME (mutant) + hexasaccharide<br />
-**[[2ntp]], [[2ntb]], [[2ntq]] – EcME + hexasaccharide
-*Aclacinomycin methylesterase
-**[[1q0r]], [[1q0z]] – ME + product analog – ''Streptomyces purpurascens''
-*Protein phosphatase methylesterase
-**[[3c5v]] – hME1 – human<br />
-**[[3c5w]] – hME1 + protein phosphatase 2A
-*4-o-methyl-glucuronoyl methylesterase
-**[[4g4g]] – MtME – ''Myceliophthora thermophila''<br />
-**[[4g4i]] – MtME (mutant)<br />
-**[[4g4j]] – MtME (mutant) + 4-o-methyl-β-D-glucopyranuronate<br />
-*CheB methylesterase see [[Chemotaxis protein]]
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]